Kontaxakis V, Markianos M, Markidis M, Stefanis C
Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.
Acta Psychiatr Scand. 1989 Jan;79(1):108-10. doi: 10.1111/j.1600-0447.1989.tb09242.x.
In a mixed bipolar disorder patient, DST-positive, treated with neuroleptics and antidepressants, the addition of clonidine (up to 0.6 mg/day) caused a rapid improvement in his psychopathology, without any significant side effects. The concentrations of the metabolites of noradrenaline, dopamine, and serotonin (MHPG, HVA, and 5-HIAA), the hormone prolactin and the activity of dopamine-beta-hydroxylase estimated in plasma during the clonidine trial are also reported.
在一名双相情感障碍混合型患者中，该患者地塞米松抑制试验阳性，正在接受抗精神病药物和抗抑郁药物治疗，加用可乐定（剂量高达0.6毫克/天）后其精神病理学症状迅速改善，且无任何明显副作用。文中还报告了在可乐定试验期间血浆中去甲肾上腺素、多巴胺和5-羟色胺的代谢产物（3-甲氧基-4-羟基苯乙二醇、高香草酸和5-羟吲哚乙酸）、激素催乳素的浓度以及多巴胺-β-羟化酶的活性。
