Sripada Rebecca K, Swain James E, Evans Gary W, Welsh Robert C, Liberzon Israel
1] Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA [2] Veterans Affairs Serious Mental Illness Treatment Resource and Evaluation Center (SMITREC), Ann Arbor, MI, USA [3] Veterans Affairs Ann Arbor Health Care System, Ann Arbor, MI, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Neuropsychopharmacology. 2014 Aug;39(9):2244-51. doi: 10.1038/npp.2014.75. Epub 2014 Mar 28.
Convergent research suggests that childhood poverty is associated with perturbation in the stress response system. This might extend to aberrations in the connectivity of large-scale brain networks, which subserve key cognitive and emotional functions. Resting-state brain activity was measured in adults with a documented history of childhood poverty (n=26) and matched controls from middle-income families (n=26). Participants also underwent a standard laboratory social stress test and provided saliva samples for cortisol assay. Childhood poverty was associated with reduced default mode network (DMN) connectivity. This, in turn, was associated with higher cortisol levels in anticipation of social stress. These results suggest a possible brain basis for exaggerated stress sensitivity in low-income individuals. Alterations in DMN may be associated with less efficient cognitive processing or greater risk for development of stress-related psychopathology among individuals who experienced the adversity of chronic childhood poverty.
多项研究表明，童年贫困与应激反应系统的紊乱有关。这可能会延伸到大规模脑网络连接的异常，而这些网络负责关键的认知和情感功能。对有童年贫困记录的成年人（n = 26）和来自中等收入家庭的匹配对照组（n = 26）进行了静息态脑活动测量。参与者还接受了标准的实验室社会应激测试，并提供唾液样本进行皮质醇检测。童年贫困与默认模式网络（DMN）连接性降低有关。反过来，这又与预期社会应激时较高的皮质醇水平有关。这些结果表明，低收入个体应激敏感性过高可能存在脑基础。DMN的改变可能与认知处理效率较低或在经历慢性童年贫困逆境的个体中发生与应激相关精神病理学的风险较高有关。
