Lakspere Triin, Kallio-Kokko Hannimari, Kantele Anu, Mattila Pirkko, Almusa Henrikki, Kainov Denis, Kakkola Laura
The Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
Genome Announc. 2014 Mar 27;2(2):e00039-14. doi: 10.1128/genomeA.00039-14.
Here, we sequenced 10 influenza A(H3N2) virus genomes isolated from Finnish patients diagnosed with flu-like illness during the 2012-2013 influenza season. The alignment showed a high number of amino acid substitutions (238 in total) in only 10 samples, proving that a high mutation rate exists in seasonal influenza A viruses.
在此,我们对从2012 - 2013年流感季节被诊断患有流感样疾病的芬兰患者身上分离出的10个甲型H3N2流感病毒基因组进行了测序。序列比对显示,仅10个样本中就存在大量氨基酸替换(总计238个),这证明季节性甲型流感病毒存在高突变率。