Department of Neuropsychiatry, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
Psinapsys Psychiatric Private Center, La Plata, Argentina.
Braz J Psychiatry. 2014 Apr-Jun;36(2):106-10. doi: 10.1590/1516-4446-2013-1221. Epub 2014 Mar 24.
Pregnant women and their health care professionals commonly believe that use of medications during pregnancy may be harmful to the unborn fetus. The objective of this study was to evaluate the risk perception of psychotropic drug use in pregnancy among physicians in different medical specialties.
This was a convenience survey conducted at outpatient clinics in the cities of Recife, Brazil, and La Plata, Bahía Blanca, and Buenos Aires, Argentina. Physicians who agreed to participate were asked to rate their perception of teratogenic risk among different classes of drugs, which included antidepressants, antipsychotics, anticonvulsants, and benzodiazepines.
Two hundred and thirty-eight physicians completed the survey (response rate, 98%). These included psychiatrists, obstetricians, neurologists, cardiologists, gastroenterologists, and general practitioners. Among different specialties, a minority of psychiatrists perceived psychotropic drugs to be highly teratogenic (antidepressants, 12.5%; antipsychotics, 15%; benzodiazepines, 25%) as compared with other specialties (p < 0.003 for each drug class). There was no difference in perceived risk of antiepileptic drugs among specialties, including psychiatrists.
The risk associated with use of psychotropic drugs in pregnancy was overestimated by physicians of all medical specialties, except psychiatry. All physicians should be aware of the safety/risk of psychotropic agents in pregnancy, as they may be required to give advice and/or prescribe these drugs to pregnant women.
孕妇及其医疗保健专业人员普遍认为，怀孕期间使用药物可能对胎儿有害。本研究的目的是评估不同医学专业医生对妊娠期间使用精神药物的风险感知。
这是在巴西累西腓市和阿根廷的拉普拉塔、巴伊亚布兰卡和布宜诺斯艾利斯市的门诊诊所进行的一项便利调查。同意参与的医生被要求评估不同类别的药物（包括抗抑郁药、抗精神病药、抗惊厥药和苯二氮䓬类药物）的致畸风险感知。
共有 238 名医生完成了调查（应答率为 98%）。这些医生包括精神科医生、产科医生、神经科医生、心脏病专家、胃肠病专家和全科医生。在不同的专业中，少数精神科医生认为精神药物具有高度致畸性（抗抑郁药为 12.5%；抗精神病药为 15%；苯二氮䓬类药物为 25%），而其他专业的医生则认为精神药物的致畸性较低（每种药物类别均为 p < 0.003）。包括精神科医生在内，各专业医生对抗癫痫药物的风险感知没有差异。
除了精神病学之外，所有医学专业的医生都高估了妊娠期间使用精神药物的风险。所有医生都应该了解精神药物在妊娠期间的安全性/风险，因为他们可能需要向孕妇提供建议和/或开这些药物。
