Berretta Roberto, Patrelli Tito Silvio, Migliavacca Costanza, Rolla Martino, Franchi Laura, Monica Michela, Modena Alberto Bacchi, Gizzo Salvatore
Department of Surgical Sciences, University of Parma, Parma, Italy.
Department of Women and Child Health, University of Padua, Padua, Italy.
Oncol Rep. 2014 May;31(5):2407-12. doi: 10.3892/or.2014.3108. Epub 2014 Mar 21.
Accumulating evidence suggests that the estimation of tumor size may improve endometrial cancer treatment. We conducted an observational study aimed at elucidating the association between tumor size and other universally accepted prognostic factors in order to identify suitable preoperative parameters which can guide surgery in a subgroup of early corpus endometrial cancer. We found that when tumor size increased, both stage and grading were significantly increased. Tumor size was correlated with CA 125 serum values, node metastasis and peritoneal cytology status. Patients who have grade 1 or 2 endometrioid corpus cancer, myometrial invasion < 50% and ≤ 3 cm largest tumor diameter can only be treated with hysterectomy. The tumor largest diameter should be evaluated as a preoperative parameter that indicates patients who do not require lymphadenectomy.
越来越多的证据表明，肿瘤大小的评估可能会改善子宫内膜癌的治疗。我们进行了一项观察性研究，旨在阐明肿瘤大小与其他普遍接受的预后因素之间的关联，以便确定合适的术前参数，从而在早期子宫内膜癌的一个亚组中指导手术。我们发现，随着肿瘤大小增加，分期和分级均显著升高。肿瘤大小与CA 125血清值、淋巴结转移及腹腔细胞学状态相关。患有1级或2级子宫内膜样癌、肌层浸润<50%且最大肿瘤直径≤3 cm的患者仅需行子宫切除术。肿瘤最大直径应作为一个术前参数进行评估，以表明哪些患者不需要进行淋巴结清扫术。
