食欲肽A神经元而非促黑素细胞激素神经元参与大鼠食物摄入的短期调节。
Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats.
作者信息
Nishimura Yuri, Mabuchi Kaori, Taguchi Sayumi, Ikeda Saori, Aida Eri, Negishi Hiroko, Takamata Akira
机构信息
Department of Environmental Health, Nara Women's University, Kitauoya Nishimachi, Nara, 630-8506, Japan.
出版信息
J Physiol Sci. 2014 May;64(3):203-11. doi: 10.1007/s12576-014-0312-0. Epub 2014 Mar 28.
Abstract
In order to elucidate the involvement of melanin-concentrating hormone (MCH) and orexin-A (ORX-A) neurons of the perifornical/lateral hypothalamic areas (PF/LH) in the regulation of food intake induced by acutely reduced glucose availability, we examined the food intake response and c-Fos expression in the MCH and ORX-A neurons in the PF/LH during 2-deoxy-D-glucose (2DG)-induced glucoprivation (400 mg/kg; i.v.) and systemic insulin-induced hypoglycemia (5 U/kg; s.c.) in male Wistar rats. The administration of both 2DG and insulin stimulated food intake and induced c-Fos expression in the ORX-A neurons corresponding to food intake, but not in the MCH neurons. These data indicate that ORX-A neurons, but not MCH neurons, play a role in the short-term regulation of food intake, and that the input signals for the neurons containing MCH and ORX-A are different, and these neurons play different roles in the regulation of feeding behavior.
摘要
为了阐明穹窿周/下丘脑外侧区（PF/LH）的促黑素细胞激素（MCH）和食欲素A（ORX-A）神经元在急性葡萄糖供应减少诱导的食物摄入调节中的作用，我们检测了雄性Wistar大鼠在2-脱氧-D-葡萄糖（2DG）诱导的糖剥夺（400mg/kg；静脉注射）和全身胰岛素诱导的低血糖（5U/kg；皮下注射）过程中，PF/LH中MCH和ORX-A神经元的食物摄入反应及c-Fos表达。2DG和胰岛素的给药均刺激了食物摄入，并在与食物摄入相应的ORX-A神经元中诱导了c-Fos表达，但在MCH神经元中未诱导。这些数据表明，ORX-A神经元而非MCH神经元在食物摄入的短期调节中起作用，并且含有MCH和ORX-A的神经元的输入信号不同，这些神经元在进食行为调节中发挥不同作用。
相似文献
1
Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats.食欲肽A神经元而非促黑素细胞激素神经元参与大鼠食物摄入的短期调节。
J Physiol Sci. 2014 May;64(3):203-11. doi: 10.1007/s12576-014-0312-0. Epub 2014 Mar 28.
2
Selective Fos induction in hypothalamic orexin/hypocretin, but not melanin-concentrating hormone neurons, by a learned food-cue that stimulates feeding in sated rats.由已饱食大鼠进食刺激的学习性食物线索选择性诱导下丘脑食欲素/下丘脑分泌素神经元，而非黑皮质素-4 神经元的 Fos 表达。
Neuroscience. 2012 Nov 8;224:70-80. doi: 10.1016/j.neuroscience.2012.08.036. Epub 2012 Aug 23.
3
Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats.神经肽Y、食欲素-I（阿立新A）和促黑素细胞激素对大鼠进食的相互作用。
Brain Res. 2002 Jul 19;944(1-2):232-8. doi: 10.1016/s0006-8993(02)02941-4.
4
Lesion of NPY Receptor-expressing Neurons in Perifornical Lateral Hypothalamus Attenuates Glucoprivic Feeding.室旁外侧下丘脑表达 NPY 受体神经元的损伤可减弱糖饥饿性摄食。
Endocrinology. 2024 Mar 29;165(5). doi: 10.1210/endocr/bqae021.
5
Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons.调节食物摄入的肽：诱导食欲的伏隔核操作激活下丘脑食欲素神经元并抑制促黑素细胞激素神经元。
Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1436-44. doi: 10.1152/ajpregu.00781.2002. Epub 2003 Jan 23.
6
Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation.大鼠下丘脑外侧区中含食欲肽和促黑素细胞激素的神经元之间的相互突触关系：涉及进食调节的新神经回路。
Int J Obes Relat Metab Disord. 2002 Dec;26(12):1523-32. doi: 10.1038/sj.ijo.0802155.
7
Multi-transcriptional profiling of melanin-concentrating hormone and orexin-containing neurons.黑色素聚集激素和含食欲素神经元的多转录组分析
Cell Mol Neurobiol. 2005 Dec;25(8):1209-23. doi: 10.1007/s10571-005-8184-8.
8
Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle.在整个睡眠-觉醒周期中，促黑素细胞激素神经元与食欲素神经元以相互的方式放电。
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2418-22. doi: 10.1073/pnas.0811400106. Epub 2009 Feb 2.
9
Peripheral ghrelin interacts with orexin neurons in glucostatic signalling.外周胃饥饿素在葡萄糖稳态信号传导中与食欲素神经元相互作用。
Regul Pept. 2007 Dec 4;144(1-3):17-24. doi: 10.1016/j.regpep.2007.05.006. Epub 2007 Jun 2.
10
Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats.喹啉酸盐诱导小鼠和幼鼠下丘脑黑色素浓缩激素神经元而非食欲素神经元的选择性丧失。
Neuroscience. 2010 Sep 29;170(1):298-307. doi: 10.1016/j.neuroscience.2010.06.081. Epub 2010 Jul 8.
引用本文的文献
1
Lesion of NPY Receptor-expressing Neurons in Perifornical Lateral Hypothalamus Attenuates Glucoprivic Feeding.室旁外侧下丘脑表达 NPY 受体神经元的损伤可减弱糖饥饿性摄食。
Endocrinology. 2024 Mar 29;165(5). doi: 10.1210/endocr/bqae021.
2
Activation of neurons in the insular cortex and lateral hypothalamus during food anticipatory period caused by food restriction in mice.在限制食物摄取的情况下，老鼠在食物预期期内，其脑岛皮层和外侧下丘脑的神经元被激活。
J Physiol Sci. 2023 Dec 8;73(1):34. doi: 10.1186/s12576-023-00892-2.
3
Effects of the POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes.促黑素细胞激素原系统对葡萄糖稳态的影响以及肥胖症和糖尿病的潜在治疗靶点
Diabetes Metab Syndr Obes. 2022 Sep 25;15:2939-2950. doi: 10.2147/DMSO.S380577. eCollection 2022.
4
Endogenous Androgens Diminish Food Intake and Activation of Orexin A Neurons in Response to Reduced Glucose Availability in Male Rats.内源性雄激素可减少雄性大鼠对葡萄糖减少的食物摄入和食欲素 A 神经元的激活。
Nutrients. 2022 Mar 15;14(6):1235. doi: 10.3390/nu14061235.
5
Involvement of orexin/hypocretin in the expression of social play behaviour in juvenile rats.食欲素/下丘脑泌素参与幼鼠社会玩耍行为的表达。
Int J Play. 2020;9(1):108-127. doi: 10.1080/21594937.2020.1720132. Epub 2020 Feb 9.
6
Fluoxetine Mimics the Anorectic Action of Estrogen and Its Regulation of Circadian Feeding in Ovariectomized Female Rats.氟西汀模拟雌激素的厌食作用及其对去卵巢雌性大鼠昼夜摄食的调节。
Nutrients. 2020 Mar 22;12(3):849. doi: 10.3390/nu12030849.
7
Effects of estradiol on lactoprivic signaling of the hindbrain upon the contraregulatory hormonal response and metabolic neuropeptide synthesis in hypoglycemic female rats.雌激素对低血糖雌性大鼠后脑的抗利尿激素信号转导对代谢神经肽合成的影响。
Neuropeptides. 2018 Aug;70:37-46. doi: 10.1016/j.npep.2018.05.004. Epub 2018 May 17.
8
Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses.奖赏信号与食欲调节肽系统在食物线索反应控制中的整合。
Br J Pharmacol. 2015 Nov;172(22):5225-38. doi: 10.1111/bph.13321. Epub 2015 Nov 1.
9
Direct hypothalamic and indirect trans-pallidal, trans-thalamic, or trans-septal control of accumbens signaling and their roles in food intake.直接下丘脑和间接苍白球内、丘脑间或隔区对伏隔核信号的控制及其在摄食中的作用。
Front Syst Neurosci. 2015 Feb 13;9:8. doi: 10.3389/fnsys.2015.00008. eCollection 2015.
10
Trans and interesterified fat and palm oil during the pregnancy and lactation period inhibit the central anorexigenic action of insulin in adult male rat offspring.孕期和哺乳期摄入反式脂肪、酯交换脂肪及棕榈油会抑制成年雄性大鼠后代胰岛素的中枢性厌食作用。
J Physiol Sci. 2015 Jan;65(1):131-8. doi: 10.1007/s12576-014-0351-6. Epub 2014 Nov 15.
本文引用的文献
1
Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats.食物剥夺对血清素缺乏大鼠下丘脑进食调节肽基因表达的影响。
J Physiol Sci. 2014 Mar;64(2):97-104. doi: 10.1007/s12576-013-0296-1. Epub 2013 Oct 27.
2
Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons.葡萄糖激酶抑制剂氨基葡萄糖刺激摄食，并激活下丘脑神经肽 Y 和食欲素神经元。
Behav Brain Res. 2011 Sep 12;222(1):274-8. doi: 10.1016/j.bbr.2011.03.043. Epub 2011 Apr 1.
3
Multiple hypothalamic circuits sense and regulate glucose levels.多个下丘脑回路感知和调节血糖水平。
Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R47-55. doi: 10.1152/ajpregu.00527.2010. Epub 2010 Nov 3.
4
Sex differences in the responses of orexin neurons in the lateral hypothalamic area and feeding behavior to fasting.
Neurosci Lett. 2009 Sep 29;463(1):31-4. doi: 10.1016/j.neulet.2009.07.035. Epub 2009 Jul 16.
5
Melanin-concentrating hormone producing neurons: Activities and modulations.黑素细胞集中激素产生神经元：活动和调制。
Peptides. 2009 Nov;30(11):2031-9. doi: 10.1016/j.peptides.2009.05.028. Epub 2009 Jun 11.
6
Measurement of immediate-early gene activation- c-fos and beyond.即刻早期基因激活的测量——c-fos及其他相关基因。
J Neuroendocrinol. 2008 Jun;20(6):665-72. doi: 10.1111/j.1365-2826.2008.01734.x.
7
NPY/AgRP neurons are not essential for feeding responses to glucoprivation.神经肽Y/刺鼠相关蛋白神经元对于糖剥夺引起的进食反应并非必不可少。
Peptides. 2007 Feb;28(2):214-25. doi: 10.1016/j.peptides.2006.08.036. Epub 2006 Dec 27.
8
Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis.胰岛素受体底物-2在参与能量稳态的脑区中的分布。
Brain Res. 2006 Sep 27;1112(1):169-78. doi: 10.1016/j.brainres.2006.06.109. Epub 2006 Aug 22.
9
Metabolic sensing neurons and the control of energy homeostasis.代谢感知神经元与能量稳态的调控
Physiol Behav. 2006 Nov 30;89(4):486-9. doi: 10.1016/j.physbeh.2006.07.003. Epub 2006 Aug 8.
10
Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3',5'-monophosphate response element-binding protein.
Endocrinology. 2005 Aug;146(8):3325-33. doi: 10.1210/en.2005-0078. Epub 2005 May 19.
Zotero 插件