From the Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan (P.-C.C., K.-L.C.); Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, and National Taiwan University, College of Medicine, Taipei, Taiwan (S.-H.Y., M.-F.K.); and National Taiwan University Health Data Research Center, Taipei, Taiwan (I.-J.T.).
Stroke. 2014 May;45(5):1258-63. doi: 10.1161/STROKEAHA.113.004160. Epub 2014 Mar 27.
Previous studies have shown regional and temporal variations in epidemiological features of moyamoya disease, but population-based studies in regions other than Japan are limited. We investigated the incidence and patients characteristics of moyamoya disease during 12 years in Taiwan using claims databases of a universal health insurance system.
From the inpatient databases of the Taiwan National Health Insurance program, we identified subjects who had an initial hospitalization with moyamoya disease and had been underwent cerebral angiography as incidence cases during 2000 to 2011. The incidence and the patient characteristics were described by age and time periods of the hospitalization.
During the 12-year period, 422 patients were identified, representing an annual incidence of 0.15 per 100,000 person-years. Adults exhibited an upward trend in incidence with an incidence rate ratio of 1.74 (95% confidence interval [1.17-2.58]) in years 2010 to 2011 comparing with years 2000 to 2001. However, children had a decreased incidence except a slightly increase in the last 2 years. Compared with patients hospitalized during 2000 to 2005, patients identified during 2006 to 2011 had greater women-to-men ratio (1.7 versus 1.1, P=0.048). Children were more likely to have comorbid epilepsy than were adult patients (25.0% versus 3.4%, P=0.002). Hemorrhagic stroke was rare among pediatric patients but presented more frequently in adults. However, ischemic stroke was more prevalent in both groups.
The incidence of moyamoya disease has increased in adults but not in children from 2000 to 2011 in Taiwan. Sex ratio and comorbid conditions differed by age and study period.
先前的研究表明，烟雾病的流行病学特征存在区域性和时间性差异，但日本以外地区基于人群的研究有限。我们利用全民健康保险制度的住院数据库，调查了台湾在 12 年间烟雾病的发病率和患者特征。
从 2000 年至 2011 年，我们从全民健康保险计划的住院数据库中确定了患有烟雾病且首次住院并接受脑血管造影的患者作为发病率病例。发病率和患者特征按年龄和住院时间段进行描述。
在 12 年期间，共确定了 422 例患者，每年发病率为 0.15/10 万人年。成人的发病率呈上升趋势，与 2000 年至 2001 年相比，2010 年至 2011 年的发病率比为 1.74（95%置信区间[1.17-2.58]）。然而，儿童的发病率除了在最后 2 年略有增加外呈下降趋势。与 2000 年至 2005 年住院的患者相比，2006 年至 2011 年住院的患者中女性与男性的比例更高（1.7 比 1.1，P=0.048）。与成年患者相比，儿童更有可能合并癫痫（25.0%比 3.4%，P=0.002）。儿童中很少发生出血性中风，但在成年患者中更为常见。然而，缺血性中风在两组中更为普遍。
在台湾，2000 年至 2011 年间，烟雾病在成人中的发病率增加，但在儿童中未增加。性别比例和合并症的发病情况因年龄和研究时间段而异。
