给予治疗的强度对采用POMB/ACE化疗的生殖细胞肿瘤治疗结果的影响。
The effect of intensity of administered treatment on the outcome of germ cell tumours treated with POMB/ACE chemotherapy.
作者信息
Crawford S M, Newlands E S, Begent R H, Rustin G J, Bagshawe K D
机构信息
Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross Hospital, London, UK.
出版信息
Br J Cancer. 1989 Feb;59(2):243-6. doi: 10.1038/bjc.1989.49.
In order to assess the importance of the intensity of administration of chemotherapy in the management of advanced germ cell tumours we have calculated indices of chemotherapy. These have been used to compare the treatment given to patients who subsequently relapsed with matched controls who did not relapse. Two of these indices (alpha and beta) are derived from the doses of drugs whose dose is varied (cisplatinum, methotrexate and etoposide). These indices showed significant variation between cases and controls. Indices gamma and delta are derived from drugs whose dose is not varied. They showed no significant differences between the two groups. These results emphasise the importance of ensuring that patients with these curable cancers receive adequate doses of chemotherapy.
为了评估化疗强度在晚期生殖细胞肿瘤治疗中的重要性，我们计算了化疗指数。这些指数用于比较后续复发患者与未复发的匹配对照患者所接受的治疗。其中两个指数（α和β）源自剂量可变的药物（顺铂、甲氨蝶呤和依托泊苷）。这些指数在病例组和对照组之间显示出显著差异。指数γ和δ源自剂量不变的药物。两组之间未显示出显著差异。这些结果强调了确保这些可治愈癌症患者接受足够剂量化疗的重要性。
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