半量钆布醇与标准剂量钆喷酸葡胺用于非肝硬化肝脏动态磁共振成像的回顾性个体内交叉比较

Half-dose gadobenate dimeglumine versus standard-dose gadodiamide in dynamic magnetic resonance imaging of non-cirrhotic livers: a retrospective intra-individual crossover comparison.

作者信息

Homayoon Behrang, Diwakar Himanshu, Strovski Evgeny, Bakshi Darshan, Harris Alison C, Thoeni Ruedi F, Chang Silvia D

机构信息

Department of Diagnostic Radiology, University of British Columbia, 3350-950 W 10th Avenue, Vancouver, BC, V5Z 4E3, Canada,

出版信息

Abdom Imaging. 2014 Oct;39(5):955-62. doi: 10.1007/s00261-014-0123-z.

DOI:10.1007/s00261-014-0123-z

PMID:24676875

Abstract

PURPOSE

The purpose of this study was to compare enhancement characteristics of half-dose gadobenate dimeglumine (0.05 mmol kg(-1)) with standard-dose gadodiamide (0.10 mmol kg(-1)), in the assessment of hepatic vessels and lesions, using retrospective intra-individual crossover comparison methodology.

METHODS

Ethics committee approval was obtained. From 2004 to 2012, 21 patients underwent MRI examination with both standard-dose gadodiamide and half-dose gadobenate dimeglumine, using the same liver MRI protocol at 1.5 T. Eighteen patients whose scans showed no artifacts were selected. Quality of liver lesion [12 hemangiomas, 7 focal nodular hyperplasias (FNHs)] and liver vessel enhancement, and the global diagnostic quality of studies were ranked on a scale of 1-4 by two independent radiologists. Contrast-to-noise ratio (CNR) and % enhancement of liver vessels and lesions were calculated based on region of interest, signal intensity, and noise standard deviation measurements performed at 0, 20 s, 1, 3, and 5 min post-contrast injection. Qualitative and quantitative results were compared using the paired Wilcoxon signed rank and Student's t-tests, respectively.

RESULTS

No qualitative differences were noted in enhancement of liver vessels, hemangiomas, and FNHs. There was no statistically significant difference between the global diagnostic qualities of scans performed with the two contrast agents. Quantitatively, liver vessels and hemangiomas did not demonstrate statistically significant differences in contrast enhancement. At 20 s, FNHs achieved higher CNR (P = 0.02) with gadodiamide.

CONCLUSION

Half-dose gadobenate dimeglumine results in similar contrast enhancement compared to standard-dose gadodiamide in assessment of liver vessels, hemangiomas, and FNHs, and is a reasonable alternative to standard doses of extracellular agents in dynamic liver MRI.

摘要

目的

本研究旨在采用回顾性个体内交叉比较方法，比较半剂量钆贝葡胺（0.05 mmol/kg）与标准剂量钆双胺（0.10 mmol/kg）在评估肝血管和病变时的增强特征。

方法

获得伦理委员会批准。2004年至2012年期间，21例患者在1.5 T场强下使用相同的肝脏MRI方案，先后接受了标准剂量钆双胺和半剂量钆贝葡胺的MRI检查。选取18例扫描未显示伪影的患者。两名独立放射科医生对肝脏病变[12个血管瘤、7个局灶性结节性增生（FNH）]和肝血管增强的质量以及研究的整体诊断质量进行1-4级评分。根据感兴趣区、信号强度以及对比剂注射后0、20秒、1、3和5分钟时的噪声标准差测量值，计算肝血管和病变的对比噪声比（CNR）及增强百分比。分别采用配对Wilcoxon符号秩检验和Student's t检验比较定性和定量结果。