M2毒蕈碱受体激动剂注入孤束核时会引起低血压和心动过缓。

M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii.

作者信息

Sundaram K, Murugaian J, Watson M, Sapru H

机构信息

Section of Neurosurgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103.

出版信息

Brain Res. 1989 Jan 16;477(1-2):358-62. doi: 10.1016/0006-8993(89)91427-3.

DOI:10.1016/0006-8993(89)91427-3

PMID:2467726

Abstract

Bilateral microinjections (0.2-2 nmol/site) of a potent M2 muscarinic receptor agonist, cis-methyldioxolane (CD), but not those of a relatively selective M1 receptor agonist (McN-A343; 3 nmol/site), into the intermediate portion of nucleus tractus solitarii (NTS) of pentobarbital-anesthetized rats elicited a decrease in blood pressure (23-52 mm Hg) and heart rate (16-50 bpm). Previous microinjections of a selective competitive M2 receptor antagonist (AFDX-116; 0.8 nmol/site), but not those of a potent selective M1 receptor antagonist (pirenzepine; 2 nmol/site), into the NTS blocked the effects of CD. These results indicate that the muscarinic receptors in the intermediate portion of NTS are of M2 type.

摘要

向戊巴比妥麻醉的大鼠孤束核（NTS）中间部分双侧微量注射（0.2 - 2 nmol/位点）强效M2毒蕈碱受体激动剂顺式甲基二氧戊环（CD），而非相对选择性的M1受体激动剂（McN - A343；3 nmol/位点），可引起血压下降（23 - 52 mmHg）和心率降低（16 - 50 bpm）。先前向NTS中微量注射选择性竞争性M2受体拮抗剂（AFDX - 116；0.8 nmol/位点），而非强效选择性M1受体拮抗剂（哌仑西平；2 nmol/位点），可阻断CD的作用。这些结果表明，NTS中间部分的毒蕈碱受体为M2型。