儿童对阿莫西林的严重迟发型超敏反应。
Severe delayed-onset hypersensitivity reactions to amoxicillin in children.
作者信息
Chopra R, Roberts J, Warrington R J
机构信息
Department of Medicine, University of Manitoba, Winnipeg.
出版信息
CMAJ. 1989 Apr 15;140(8):921-3.
Amoxicillin, a semisynthetic aminopenicillin, has achieved widespread use in recent years for the treatment of respiratory tract and otic infections. Serious reactions have been relatively infrequent. From July 1986 to June 1987, 11 children aged 6 months to 10 years presented with delayed-onset hypersensitivity reactions. In 10 the symptoms were consistent with a serum-sickness-like illness, including urticaria, angioedema, arthritis and arthralgia. Radioallergosorbent testing for IgE antibodies to penicillin yielded negative results, and lymphocyte transformation testing gave a positive result in only one patient. Because of the negative immunologic test results and the occurrence of reactions only in children, who had received an amoxicillin solution, the reactions may have been caused by the excipient.
阿莫西林是一种半合成氨基青霉素，近年来已广泛用于治疗呼吸道和耳部感染。严重反应相对较少见。1986年7月至1987年6月，11名6个月至10岁的儿童出现迟发性过敏反应。其中10名儿童的症状符合血清病样疾病，包括荨麻疹、血管性水肿、关节炎和关节痛。针对青霉素IgE抗体的放射变应原吸附试验结果为阴性，淋巴细胞转化试验仅在一名患者中呈阳性。由于免疫检测结果为阴性，且反应仅发生在接受阿莫西林溶液治疗的儿童中，这些反应可能是由辅料引起的。
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