白细胞介素-1 超家族的结构生物学：调节免疫和炎症反应的关键细胞因子。
Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses.
机构信息
Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, 74078.
出版信息
Protein Sci. 2014 May;23(5):526-38. doi: 10.1002/pro.2441. Epub 2014 Mar 4.
Abstract
Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.
摘要
白细胞介素-1 超家族细胞因子（IL-1、IL-18、IL-33）在炎症和免疫调节中发挥关键作用。结构生物学家近 20 年来一直在研究 IL-1 超家族中激动剂和拮抗剂的作用机制。最近，IL-1β及其受体的三元复合物晶体结构提供了对这些机制的新见解。我们将在这里回顾与白细胞介素-1 超家族细胞因子的受体识别以及拮抗剂对其细胞因子活性的调节相关的结构生物学。
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本文引用的文献
1
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Semin Immunol. 2013 Dec 15;25(6):389-93. doi: 10.1016/j.smim.2013.10.001. Epub 2013 Nov 23.
2
Interleukin-18 and IL-18 binding protein.白细胞介素-18与白细胞介素-18结合蛋白。
Front Immunol. 2013 Oct 8;4:289. doi: 10.3389/fimmu.2013.00289.
3
Structural insights into the interaction of IL-33 with its receptors.IL-33 与其受体相互作用的结构见解。
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14918-23. doi: 10.1073/pnas.1308651110. Epub 2013 Aug 26.
4
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Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3913-8. doi: 10.1073/pnas.1217996110. Epub 2013 Feb 19.
5
Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members.IL-33 的加工和分泌机制：IL-1 家族成员之间的差异和相似性。
Eur Cytokine Netw. 2012 Oct-Dec;23(4):120-7. doi: 10.1684/ecn.2012.0320.
6
A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein.鸭坦布苏病毒白细胞介素 18 结合蛋白的独特二价结合和抑制机制。
PLoS Pathog. 2012;8(8):e1002876. doi: 10.1371/journal.ppat.1002876. Epub 2012 Aug 23.
7
Structure of the activating IL-1 receptor signaling complex.IL-1 受体激活信号复合物的结构。
Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260.
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