Motegi Atsushi, Kawashima Mitsuhiko, Arahira Satoko, Zenda Sadamoto, Toshima Masamichi, Onozawa Masakatsu, Hayashi Ryuichi, Akimoto Tetsuo
Division of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Head Neck. 2015 Apr;37(4):579-84. doi: 10.1002/hed.23641. Epub 2014 Apr 10.
Accelerated fractionation radiotherapy (RT) was administered in an attempt to improve the local control rates in patients with T1/T2 N0 glottic cancer.
Medical charts of 148 consecutive patients who had undergone RT using 2.4 Gray (Gy) once-daily fractionation between July 1999 and April 2007 were reviewed.
Of 104 patients with T1 disease treated by RT, 82 received 60 Gy/25 fractions, and the remaining 22 with large tumor volumes and/or slow response to RT received 64.8 Gy/27 fractions. All 44 patients with T2 disease received 64.8 Gy/27 fractions. The 5-year local control and overall survival (OS) rates were 93% and 96%, respectively, in patients with T1 disease, and 77% and 91%, respectively, in patients with T2 disease. No severe acute toxicities were observed, although 2 patients (1%) developed severe late toxicity.
Accelerated RT for early glottic cancer is feasible, with encouraging local control rates.
采用加速分割放射治疗（RT）以试图提高T1/T2 N0声门癌患者的局部控制率。
回顾了1999年7月至2007年4月期间连续148例接受2.4格雷（Gy）每日一次分割放疗的患者的病历。
在104例接受放疗的T1期疾病患者中，82例接受60 Gy/25次分割，其余22例肿瘤体积大且/或对放疗反应缓慢的患者接受64.8 Gy/27次分割。所有44例T2期疾病患者均接受64.8 Gy/27次分割。T1期疾病患者的5年局部控制率和总生存率（OS）分别为93%和96%，T2期疾病患者分别为77%和91%。未观察到严重的急性毒性反应，尽管有2例患者（1%）出现严重的晚期毒性反应。
早期声门癌的加速放疗是可行的，局部控制率令人鼓舞。
