Evans G E, Garson M J, Griffin D A, Leeper F J, Stauton J
Ciba Found Symp. 1978(53):131-47. doi: 10.1002/9780470720349.ch9.
As a result of speculation that many enzymes control polyketone cyclization in vivo by converting a key carbonyl group to a cis-enol ether derivative, we describe two novel biomimetic cyclizations. The first involves condensation of two C6 units derived from triacetic lactone to form an arylpyrone related to aloenin. In the second a naphthapyrone of the rubrofusarin type is formed by condensation of an orsellinic acid derivative with the ether of triacetic lactone.
由于推测许多酶在体内通过将关键羰基转化为顺式烯醇醚衍生物来控制聚酮环化，我们描述了两种新型的仿生环化反应。第一种涉及由三乙酸内酯衍生的两个C6单元缩合形成与芦荟宁相关的芳基吡喃酮。第二种是通过苔色酸衍生物与三乙酸内酯的醚缩合形成红镰菌素型萘并吡喃酮。
