Zeymer U, Neuhaus K L
Medizinische Klinik II, Städtische Kliniken Kassel.
Dtsch Med Wochenschr. 1989 Apr 14;114(15):589-92. doi: 10.1055/s-2008-1066640.
Left-chest pain and infarct-like ECG changes occurred in a 47-year-old man who had had an orchiectomy for embryonic carcinoma of the testes and was receiving the second cycle of chemotherapy with vinblastine, bleomycin and cisplatin. Only creatine kinase was slightly elevated (90 U/l) among the heart-specific enzymes. Coronary angiography did not demonstrate any coronary abnormalities, but the ventriculogram showed apical akinesia. Chest pain and similar ECG changes again occurred during the third treatment cycle, this time without bleomycin. This sequence would suggest that vinblastine was the cause of the myocardial damage, although its pathogenesis is uncertain.
一名47岁男性在接受睾丸胚胎癌睾丸切除术后，正在接受长春花碱、博来霉素和顺铂的第二个化疗周期，出现了左胸痛和类似梗死的心电图变化。在心脏特异性酶中，只有肌酸激酶略有升高（90 U/l）。冠状动脉造影未显示任何冠状动脉异常，但心室造影显示心尖运动减弱。在第三个治疗周期中再次出现胸痛和类似的心电图变化，这次没有使用博来霉素。尽管其发病机制尚不确定，但这一系列情况表明长春花碱是心肌损伤的原因。
