Hamilton C R, Bliss J M, Horwich A
Department of Radiotherapy, Institute of Cancer Research, U.K.
Eur J Cancer Clin Oncol. 1989 Feb;25(2):185-9. doi: 10.1016/0277-5379(89)90006-0.
The combination of bleomycin, etoposide and cis-platinum (BEP) is an effective treatment for germ cell tumours. To help define the role of recently developed non-nephrotoxic analogues of cis-platinum we have analysed the long term renal damage caused by this agent. We report on 22 patients studied 8-60 months following BEP chemotherapy. In the 17 cases with no pre-chemotherapy renal impairment there was a fall in mean glomerular filtration rate from 132 ml/min (95% confidence interval 123, 141) pre-chemotherapy to 103 ml/min (95% confidence interval 94, 113) on late follow up. The overall pattern is one of initial fall of glomerular filtration rate during chemotherapy, and no consistent evidence of late recovery or further deterioration; considerable individual variation is observed.
博来霉素、依托泊苷和顺铂联合疗法（BEP）是治疗生殖细胞肿瘤的有效方法。为了明确最近开发的顺铂非肾毒性类似物的作用，我们分析了该药物引起的长期肾损伤。我们报告了22例在接受BEP化疗后8至60个月接受研究的患者。在17例化疗前无肾功能损害的病例中，平均肾小球滤过率从化疗前的132毫升/分钟（95%置信区间123, 141）降至后期随访时的103毫升/分钟（95%置信区间94, 113）。总体模式是化疗期间肾小球滤过率最初下降，且没有一致的证据表明后期恢复或进一步恶化；观察到个体差异很大。
