Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Rua Alexander Fleming, 101, Cidade Universitária, 13083-881 Campinas, SP, Brazil.
Endocrinology Division of Department of Clinical Medicine, School of Medical Sciences, University of Campinas, Rua Tessália Vieira de Camargo, 126, Cidade Universitária, 13083-887 Campinas, SP, Brazil.
Int J Endocrinol. 2014;2014:982705. doi: 10.1155/2014/982705. Epub 2014 Feb 11.
Objectives. To evaluate the prevalence of infertility in women with Graves' disease (GD) or Hashimoto's thyroiditis (HT) and associated factors. Material and Methods. This cross-sectional study was conducted at the Endocrinology Clinic for Thyroid Autoimmune Diseases, with 193 women aged 18-50 years with GD and 66 women aged 18-60 years with HT. The women were interviewed to obtain data on their gynecological and obstetric history and family history of autoimmune diseases. Their medical records were reviewed to determine the characteristics of the disease and to confirm association with other autoimmune diseases. Infertility was defined as 12 months of unprotected sexual intercourse without conception. Results. The prevalence of infertility was 52.3% in GD and 47.0% in HT. Mean age at diagnosis was 36.5 years and 39.2 years, in GD and HT, respectively. The mean number of pregnancies was lower in women who were 35 years old or younger at diagnosis and was always lower following diagnosis of the disease, irrespective of age. The only variable associated with infertility was a shorter time of the disease in HT. Conclusions. The prevalence of infertility was high in women with GD and HT and affected the number of pregnancies in young women.
目的。评估 Graves 病（GD）或桥本甲状腺炎（HT）女性的不孕患病率及其相关因素。材料与方法。这是一项在甲状腺自身免疫性疾病内分泌科进行的横断面研究，纳入了 193 名年龄在 18-50 岁的 GD 女性和 66 名年龄在 18-60 岁的 HT 女性。对这些女性进行访谈，以获取其妇科和产科病史以及自身免疫性疾病家族史的数据。查阅其病历，以确定疾病特征并确认与其他自身免疫性疾病的关联。不孕定义为未采取避孕措施的 12 个月性行为未受孕。结果。GD 中的不孕患病率为 52.3%，HT 中的不孕患病率为 47.0%。GD 和 HT 中女性的诊断时平均年龄分别为 36.5 岁和 39.2 岁。诊断前年轻的女性怀孕次数较低，且无论年龄大小，在诊断后怀孕次数总是更低。与不孕相关的唯一变量是 HT 中疾病持续时间更短。结论。GD 和 HT 女性的不孕患病率较高，且影响年轻女性的怀孕次数。
