Colorectal Dis. 2014 Mar;16(3):O112-6. doi: 10.1111/codi.12502.
Solitary rectal ulcer syndrome (SRUS) is uncommon and its management is controversial. The aim of this study was to evaluate the outcome of patients with SRUS who underwent laparoscopic ventral rectopexy (LVR).
A review was performed of a prospective database at the Oxford Pelvic Floor Centre to identify patients between 2004 and 2012 with a histological diagnosis of SRUS. All were initially treated conservatively and surgical treatment was indicated only for patients with significant symptoms after failed conservative management. The primary end-point was healing of the ulcer. Secondary end-points included changes in the Wexner Constipation Score and Faecal Incontinence Severity Index (FISI).
Thirty-six patients with SRUS were identified (31 women), with a median age of 44 (15–81) years. The commonest symptoms were rectal bleeding (75%) and obstructed defaecation (64%). The underlying anatomical diagnosis was internal rectal prolapse (n = 20), external rectal prolapse (n = 14) or anismus (n = 2). Twenty-nine patients underwent LVR and one a stapled transanal rectal resection (STARR) procedure. Nine (30%) required a further operation, six required posterior STARR for persistent SRUS and two a per-anal stricturoplasty for a narrowing at the healed SRUS site. Healing of the SRU was seen in 27 (90%) of the 30 patients and was associated with significant improvements in Wexner and FISI scores at a 3-year follow-up.
Almost all cases of SRUS in the present series were associated with rectal prolapse. LVR resulted in successful healing of the SRUS with good function in almost all patients, but a significant number will require further surgery such as STARR for persistent obstructed defaecation.
孤立性直肠溃疡综合征(SRUS)较为少见,其治疗方法存在争议。本研究旨在评估接受腹腔镜下腹膜前直肠固定术(LVR)治疗的 SRUS 患者的结局。
对牛津盆底中心前瞻性数据库进行了回顾性分析,以确定 2004 年至 2012 年间组织学诊断为 SRUS 的患者。所有患者均先接受保守治疗,仅对保守治疗失败后症状明显的患者进行手术治疗。主要终点为溃疡愈合。次要终点包括 Wexner 便秘评分和粪便失禁严重程度指数(FISI)的变化。
共确定 36 例 SRUS 患者(31 例女性),平均年龄为 44(15-81)岁。最常见的症状是直肠出血(75%)和排便困难(64%)。潜在的解剖学诊断为直肠内脱垂(n=20)、直肠外脱垂(n=14)或肛门失弛缓症(n=2)。29 例患者接受 LVR 治疗,1 例患者接受吻合器经肛直肠切除术(STARR)治疗。9 例(30%)需要进一步手术,6 例因持续存在 SRUS 而行后位 STARR,2 例行经肛门狭窄切除术以治疗愈合处的狭窄。30 例患者中有 27 例(90%)SRU 愈合,在 3 年随访时 Wexner 和 FISI 评分显著改善。
本研究中,几乎所有 SRUS 病例均与直肠脱垂有关。LVR 可成功治愈 SRUS,几乎所有患者的功能均得到改善,但仍有相当一部分患者需要进一步手术,如 STARR 治疗持续性排便困难。