Öztürk Savaş, Öztürk Tülin, Ucak Haydar, Erden Ilker, Demir Betül, Kayalı Alperen, Cicek Demet
Department of Dermatology, Elazig Education and Research Hospital , Elazig , Turkey .
Cutan Ocul Toxicol. 2015 Mar;34(1):21-4. doi: 10.3109/15569527.2014.888079. Epub 2014 Mar 31.
Isotretinoin affects the levels of female hormones and ovaries in patients with severe acne.
This study evaluated the effects of isotretinoin on the ovarian reserve and levels of female hormones in patients with severe acne.
Thirty-two female patients with severe acne were enrolled. All the patients were treated with oral isotretinoin 0.5-2 mg/kg/d. The total cumulative dose for a full course was 120-135 mg/kg. The treatment duration ranged from 5 to 8 months. The serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels and antral follicle count (AFC) and ovarian volume (OV) were evaluated before and after treatment.
After treatment, the mean FSH, LH, and E2 levels were significantly lower than before treatment. In addition, the mean AFC and OV decreased after treatment, although the difference was not significant.
The results of this exploratory study do not demonstrate that oral isotretinoin has an impact in ovarian function. In contrast, isotretinoin affects levels of female hormones in patients with severe acne.
异维A酸会影响重度痤疮患者的女性激素水平和卵巢功能。
本研究评估异维A酸对重度痤疮患者卵巢储备功能及女性激素水平的影响。
纳入32例重度痤疮女性患者。所有患者均口服异维A酸，剂量为0.5 - 2mg/kg/d。全程累计总剂量为120 - 135mg/kg。治疗持续时间为5至8个月。在治疗前后评估血清促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇（E2）水平以及窦卵泡计数（AFC）和卵巢体积（OV）。
治疗后，FSH、LH和E2的平均水平显著低于治疗前。此外，治疗后AFC和OV的平均值有所下降，尽管差异不显著。
这项探索性研究的结果并未表明口服异维A酸对卵巢功能有影响。相反，异维A酸会影响重度痤疮患者的女性激素水平。
