酪氨酸激酶在系统性红斑狼疮中的作用及其作为治疗靶点的潜力。
The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.
机构信息
Department of Medicine and Temple Autoimmunity Center, Section of Rheumatology, Temple University, Philadelphia, PA, USA.
出版信息
Expert Rev Clin Immunol. 2014 May;10(5):573-82. doi: 10.1586/1744666X.2014.893827. Epub 2014 Mar 29.
Abstract
The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear antigens. Breakdown of tolerance is associated with alterations in T-cell and B-cell receptor signal transduction, including increased protein phosphorylation that may underlie pathogenesis and explain the characteristic hyperactivity of T and B cells and other immune cells in active disease. Tyrosine kinases play a central role in signaling processes in cells known to be important in the pathogenesis of autoimmune diseases. Considerable progress has been made in understanding the function of tyrosine kinases in immune cell signaling pathways. In this review, we will summarize the function of tyrosine kinases and their novel inhibitors from studies made in animal lupus models and systemic lupus erythematosus patients.
摘要
自身免疫性疾病系统性红斑狼疮的特征是对核抗原失去耐受性。耐受性的破坏与 T 细胞和 B 细胞受体信号转导的改变有关，包括蛋白磷酸化增加，这可能是发病机制的基础，并解释了活动期疾病中 T 和 B 细胞及其他免疫细胞的特征性过度活跃。酪氨酸激酶在已知对自身免疫性疾病发病机制重要的细胞信号转导过程中发挥核心作用。在理解酪氨酸激酶在免疫细胞信号通路中的功能方面已经取得了相当大的进展。在这篇综述中，我们将总结在动物狼疮模型和系统性红斑狼疮患者研究中发现的酪氨酸激酶及其新型抑制剂的功能。
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