生还是死？选择性自噬和细胞死亡如何控制细胞命运。
To be or not to be? How selective autophagy and cell death govern cell fate.
机构信息
Department of Immunology, St. Jude's Children's Research Hospital, Memphis, TN 38205, USA.
Center for Autophagy Research, Department of Internal Medicine, Department of Microbiology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Cell. 2014 Mar 27;157(1):65-75. doi: 10.1016/j.cell.2014.02.049.
The health of metazoan organisms requires an effective response to organellar and cellular damage either by repair of such damage and/or by elimination of the damaged parts of the cells or the damaged cell in its entirety. Here, we consider the progress that has been made in the last few decades in determining the fates of damaged organelles and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery. We further discuss the ways in which the autophagy machinery may impact the clearance and consequences of dying cells for host physiology. Failure in the proper removal of damaged organelles and/or damaged cells by selective autophagy and cell death processes is likely to contribute to developmental abnormalities, cancer, aging, inflammation, and other diseases.
后生动物机体的健康需要对细胞器和细胞损伤做出有效响应，要么通过修复这种损伤，要么通过消除细胞的受损部分或整个受损细胞。在这里，我们考虑了在过去几十年中通过涉及选择性自噬和细胞死亡机制的离散但遗传上重叠的途径来确定受损细胞器和受损细胞命运方面所取得的进展。我们进一步讨论了自噬机制可能影响清除和死亡细胞对宿主生理影响的方式。通过选择性自噬和细胞死亡过程正确清除受损细胞器和/或受损细胞的失败可能导致发育异常、癌症、衰老、炎症和其他疾病。
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