记忆的分子和系统生物学。

The molecular and systems biology of memory.

机构信息

Kavli Institute for Brain Science, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA; Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA; Departments of Neuroscience, Biochemistry and Molecular Biophysics, and Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.

Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.

出版信息

Cell. 2014 Mar 27;157(1):163-86. doi: 10.1016/j.cell.2014.03.001.

DOI:10.1016/j.cell.2014.03.001

PMID:24679534

Abstract

Learning and memory are two of the most magical capabilities of our mind. Learning is the biological process of acquiring new knowledge about the world, and memory is the process of retaining and reconstructing that knowledge over time. Most of our knowledge of the world and most of our skills are not innate but learned. Thus, we are who we are in large part because of what we have learned and what we remember and forget. In this Review, we examine the molecular, cellular, and circuit mechanisms that underlie how memories are made, stored, retrieved, and lost.

摘要

学习和记忆是我们大脑最神奇的两种能力。学习是我们获取有关世界新知识的生物过程，而记忆则是随着时间的推移保留和重建这些知识的过程。我们对世界的大部分知识和大部分技能并非天生就有，而是后天习得的。因此，我们之所以成为现在的自己，在很大程度上是因为我们所学到的东西，以及我们所记住和遗忘的东西。在这篇综述中，我们研究了记忆是如何形成、存储、检索和遗忘的分子、细胞和电路机制。