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兜兜转转——从无穷的复杂性回归简单,然后再回到复杂。

Coming full circle-from endless complexity to simplicity and back again.

机构信息

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Ludwig/MIT Center for Molecular Oncology, Cambridge, MA 02142, USA; MIT Department of Biology, Cambridge, MA 02142, USA.

出版信息

Cell. 2014 Mar 27;157(1):267-71. doi: 10.1016/j.cell.2014.03.004.

Abstract

Cell has celebrated the powers of reductionist molecular biology and its major successes for four decades. Those who have participated in cancer research during this period have witnessed wild fluctuations from times where endless inexplicable phenomenology reigned supreme to periods of reductionist triumphalism and, in recent years, to a move back to confronting the endless complexity of this disease.

摘要

四十年以来,细胞一直庆祝简化分子生物学及其主要成就的力量。在此期间参与癌症研究的人见证了从无尽的难以解释的现象学占主导地位的时期到简化论的胜利时期,以及近年来回归到面对这种疾病的无尽复杂性的时期。

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