Tsuda K, Shima H, Ura M, Takeda J, Kimura K, Nishio I, Masuyama Y
Department of Medicine, Wakayama Medical College, Japan.
J Hypertens Suppl. 1988 Dec;6(4):S539-41. doi: 10.1097/00004872-198812040-00169.
The purpose of the present study was to investigate the effects of vasoactive neuropeptides, such as substance P or neurotensin, on vascular adrenergic neurotransmission in hypertension. In perfused mesenteric vasculatures prepared from spontaneously hypertensive rats (SHR), we examined the effects of substance P and neurotensin on vascular responsiveness and noradrenaline release from the sympathetic nerve endings. Stimulation-evoked noradrenaline release and pressor responses were inhibited by substance P and neurotensin. In SHR, the noradrenaline release and pressor responses during electrical nerve stimulation were significantly greater than in Wistar-Kyoto rats (WKY). The inhibitory effects of these responses by substance P and neurotensin were attenuated in SHR compared with WKY. These results showed that substance P and neurotensin could affect the presynaptic site of the blood vessels and cause a decrease in electrically stimulated noradrenaline release from the vascular adrenergic neurons. The reduction of noradrenaline release and pressor responses by substance P and neurotensin in SHR might suggest insufficient regulation of the vascular adrenergic transmission by these vasoactive peptides in hypertension.
本研究的目的是探讨血管活性神经肽，如P物质或神经降压素，对高血压患者血管肾上腺素能神经传递的影响。在从自发性高血压大鼠（SHR）制备的灌注肠系膜血管中，我们研究了P物质和神经降压素对血管反应性以及交感神经末梢去甲肾上腺素释放的影响。P物质和神经降压素可抑制刺激诱发的去甲肾上腺素释放和升压反应。在SHR中，电刺激神经时的去甲肾上腺素释放和升压反应显著高于Wistar-Kyoto大鼠（WKY）。与WKY相比，SHR中P物质和神经降压素对这些反应的抑制作用减弱。这些结果表明，P物质和神经降压素可影响血管的突触前部位，并导致血管肾上腺素能神经元电刺激诱发的去甲肾上腺素释放减少。P物质和神经降压素在SHR中降低去甲肾上腺素释放和升压反应，可能提示在高血压中这些血管活性肽对血管肾上腺素能传递的调节不足。
