Liu Yanli, Liu Liangfa, Huang Deliang, Wang Jialing, Wu Wenming, Liu Mingbo, Zhao Jiandong, Zhao Po, An Yunxia
Department of Otorhinolaryngology Head and Neck Surgery, Chinese People's Liberation Army, General Hospital, Beijing 100853, China.
Department of Otorhinolaryngology Head and Neck Surgery, Chinese People's Liberation Army, General Hospital, Beijing 100853, China. Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. Email:
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Jan;49(1):35-8.
To summarize the clinical characteristics of inflammatory myofibroblastic tumor (IMT) in head and neck and to discuss its treatment.
Twenty-seven cases of IMT in head and neck diagnosed at the Chinese PLA General Hospital from 2004 to 2012 were analyzed retrospectively. Among the 27 patients, 12 males and 15 females, age ranged from 8 to 77 years, with a median 43 years old. Treatment included: 1 with radiotherapy, 22 with surgery, 3 with surgery and postoperative radiotherapy, one with concurrent chemoradiotherapy followed by surgery. Of the 27 cases, 5 located in the neck, 6 in the nasal and paranasal sinus, 4 in the temporal bone, 3 in the throat, 2 in the parotid gland, 2 in the lower pharynx, 1 in the mandible, 1 in the maxilla, 1 in the masseter muscle, 1 in the amygdala and 1 in the pharynx nasalis.
Following-up time was 4-85 months, with a median of 26 months. Six cases lost follow-up, 1 case with malignant transformation and died, 16 cases survived with no recurrence, 4 cases relapsed, of whom 2 were alive with tumors and 2 died.
IMT in the head and neck has a tendency to be malignancy, with certain recurrence rate and mortality. Radical excision is still the first choice of treatment for IMT in head and neck.
总结头颈部炎性肌纤维母细胞瘤（IMT）的临床特点并探讨其治疗方法。
回顾性分析2004年至2012年在中国人民解放军总医院确诊的27例头颈部IMT患者。27例患者中，男性12例，女性15例，年龄8至77岁，中位年龄43岁。治疗方法包括：1例行放疗，22例行手术，3例行手术加术后放疗，1例行同步放化疗后手术。27例中，5例位于颈部，6例位于鼻腔及鼻窦，4例位于颞骨，3例位于咽喉部，2例位于腮腺，2例位于下咽，1例位于下颌骨，1例位于上颌骨，1例位于咬肌，1例位于扁桃体，1例位于鼻咽部。
随访时间4至85个月，中位随访时间26个月。6例失访，1例恶变死亡，16例生存无复发，4例复发，其中2例带瘤生存，2例死亡。
头颈部IMT有恶变倾向，有一定的复发率和死亡率。根治性切除仍是头颈部IMT的首选治疗方法。
