Cohen Yoni, Ascher-Landsberg Jessica, Cohen Aviad, Lessing Joseph B, Grisaru Dan
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel.
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel.
Eur J Obstet Gynecol Reprod Biol. 2014 May;176:64-7. doi: 10.1016/j.ejogrb.2014.03.004. Epub 2014 Mar 12.
To investigate the values of C-reactive protein (CRP) in early pregnancy for detection of any abnormality of the conceptus and especially the condition of extra-uterine pregnancy (EUP).
In this prospective observational study, we established reference values for CRP in early pregnancy. Next, we tested whether a single, wide-range CRP measurement could serve as a diagnostic tool for abnormal first trimester pregnancy by comparing CRP levels in three different pregnancy statuses: viable intrauterine pregnancy (Group A), EUP (Group B) and delayed abortion (Group C).
CRP levels were significantly higher in normal pregnancy (Group A) compared to abnormal pregnancy (Group B+C and Group B alone). CRP level was influenced only by the pregnancy status (normal, EUP or delayed abortion) and not by age, BMI, hematocrit or gravidity. The multiple logistic regression model (adjusted for age, gravidity, gestational age, hematocrit and BMI) revealed CRP as being a predictor for normal intrauterine pregnancy.
This study examined the association between CRP levels and abnormal first trimester pregnancies. Our results support single CRP measurement as a diagnostic tool in early pregnancy.
探讨妊娠早期C反应蛋白（CRP）检测对胚胎异常特别是宫外孕（EUP）情况的价值。
在这项前瞻性观察研究中，我们建立了妊娠早期CRP的参考值。接下来，通过比较三种不同妊娠状态（宫内活胎妊娠（A组）、宫外孕（B组）和稽留流产（C组））的CRP水平，我们测试了单次、宽范围的CRP测量是否可作为孕早期异常妊娠的诊断工具。
与异常妊娠（B + C组和单独的B组）相比，正常妊娠（A组）的CRP水平显著更高。CRP水平仅受妊娠状态（正常、宫外孕或稽留流产）影响，而不受年龄、体重指数、血细胞比容或妊娠次数影响。多元逻辑回归模型（校正年龄、妊娠次数、孕周、血细胞比容和体重指数）显示CRP是宫内正常妊娠的预测指标。
本研究探讨了CRP水平与孕早期异常妊娠之间的关联。我们的结果支持单次CRP测量作为妊娠早期的诊断工具。
