Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
Trends Immunol. 2014 Jun;35(6):262-9. doi: 10.1016/j.it.2014.02.008. Epub 2014 Mar 26.
A lack of physical activity is linked to the development of many chronic diseases. It is now well established that the immune system and inflammation play a central role in the development of numerous chronic metabolic diseases including insulin resistance, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and specific types of cancer. Physical exercise elicits potent anti-inflammatory effects that are likely to account for many of the salutary actions of regular exercise on chronic metabolic diseases. Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated.
缺乏身体活动与许多慢性疾病的发展有关。现在已经确定，免疫系统和炎症在许多慢性代谢疾病的发展中起着核心作用，包括胰岛素抵抗、2 型糖尿病、动脉粥样硬化、非酒精性脂肪肝疾病和特定类型的癌症。身体运动引发强烈的抗炎作用，这可能是定期运动对慢性代谢疾病有益作用的许多原因。在这里，我们回顾了运动对慢性代谢疾病的有益作用可能通过何种抗炎和免疫调节机制来介导。
