Department of Biology, Miami University, Oxford, OH 45056, United States.
Department of Biology, Miami University, Oxford, OH 45056, United States.
Semin Cell Dev Biol. 2014 Apr;28:22-30. doi: 10.1016/j.semcdb.2014.03.004. Epub 2014 Mar 25.
HB-EGF is a member of the EGF family of ligands that is initially synthesized as a membrane-bound growth factor termed, proHB-EGF. The membrane bound proHB-EGF undergoes extensive proteolytic processing by several metalloproteinases capable of stimulating cellular proliferation. Soluble, mature HB-EGF binds to and activates EGF receptors. HB-EGF is a critical molecular component to a number of normal physiological processes including but not limited to tissue injury and wound healing, reproduction, angiogenesis and recently, adipogenesis. Misexpression of HB-EGF is linked to tumor formation and cancer including hepatocellular, pancreatic, gastric, breast, colon and melanoma, gliomas and glioblastomas. HB-EGF is a likely tool for therapeutic approaches to enhance treatment of injuries as well as a target for prevention of several cancers and obesity.
HB-EGF 是 EGF 家族配体的成员，最初作为一种膜结合生长因子被合成，称为 proHB-EGF。膜结合的 proHB-EGF 通过几种能够刺激细胞增殖的金属蛋白酶进行广泛的蛋白水解处理。可溶性成熟的 HB-EGF 与 EGF 受体结合并激活其。HB-EGF 是许多正常生理过程的关键分子组成部分，包括但不限于组织损伤和伤口愈合、生殖、血管生成，最近还有脂肪生成。HB-EGF 的异常表达与肿瘤形成和癌症有关，包括肝细胞癌、胰腺癌、胃癌、乳腺癌、结肠癌和黑色素瘤、神经胶质瘤和胶质母细胞瘤。HB-EGF 可能是一种治疗方法的工具，用于增强对损伤的治疗，也是预防几种癌症和肥胖的目标。
