Institute of Cell and Development, College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China.
Institute of Cell and Development, College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China; Department of Cell Biology and Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Dev Biol. 2014 Jun 15;390(2):93-101. doi: 10.1016/j.ydbio.2014.03.010. Epub 2014 Mar 26.
In mammals, hair cells may be damaged or lost due to genetic mutation, infectious disease, chemical ototoxicity, noise and other factors, causing permanent sensorineural deafness. Regeneration of hair cells is a basic pre-requisite for recovery of hearing in deaf animals. The inner ear stem cells in the organ of Corti and vestibular utricle are the most ideal precursors for regeneration of inner ear hair cells. This review highlights some recent findings concerning the proliferation and differentiation of inner ear stem cells. The differentiation of inner ear stem cells into hair cells involves a series of signaling pathways and regulatory factors. This paper offers a comprehensive analysis of the related studies.
在哺乳动物中，由于遗传突变、感染性疾病、化学耳毒性、噪声和其他因素，毛细胞可能受损或丢失，导致永久性感觉神经性耳聋。毛细胞的再生是聋动物听力恢复的基本前提。耳蜗和前庭椭圆囊中的内耳干细胞是内耳毛细胞再生的最理想前体细胞。本文综述了一些关于内耳干细胞增殖和分化的最新发现。内耳干细胞向毛细胞的分化涉及一系列信号通路和调节因子。本文对相关研究进行了全面分析。
