Díez Juan J, Iglesias Pedro
Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid, España; Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, España.
Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid, España.
Endocrinol Nutr. 2014 Oct;61(8):419-25. doi: 10.1016/j.endonu.2014.01.012. Epub 2014 Mar 26.
To assess whether subclinical hypothyroidism is associated to elevations in serum cholesterol and triglyceride levels in patients with type 2 diabetes.
From a total population of 1,112 patients with type 2 diabetes screened for thyroid dysfunction (thyrotropin measurement), a group of 325 patients with normal thyroid function and another group of 29 patients with subclinical hypothyroidism were selected. No patient had known dyslipidemia or was taking lipid lowering medication.
Patients with subclinical hypothyroidism had serum levels of total cholesterol (4.88 ± 0.74 mmol/L), HDL cholesterol (1.37 ± 0.34 mmol/L), LDL cholesterol (2.94 ± 0.58 mmol/L), and triglycerides (1.05 [0.88-1.41] mmol/L) that did not significantly differ from those found in euthyroid patients (4.79 ± 0.83, 1.33 ± 0.36, 2.87 ± 0.76, and 1.11 [0.81-1.43] mmol/L, respectively). Multiple regression analysis showed no association between TSH and serum lipid levels.
These results suggest that, in our population, there are no significant differences in serum cholesterol and triglyceride levels between diabetic patients with normal and reduced thyroid function.
评估2型糖尿病患者亚临床甲状腺功能减退是否与血清胆固醇和甘油三酯水平升高相关。
在1112例接受甲状腺功能障碍筛查（促甲状腺激素测定）的2型糖尿病患者中，选取325例甲状腺功能正常的患者和29例亚临床甲状腺功能减退的患者。所有患者均无已知血脂异常或正在服用降脂药物。
亚临床甲状腺功能减退患者的血清总胆固醇（4.88±0.74 mmol/L）、高密度脂蛋白胆固醇（1.37±0.34 mmol/L）、低密度脂蛋白胆固醇（2.94±0.58 mmol/L）和甘油三酯（1.05 [0.88 - 1.41] mmol/L）水平与甲状腺功能正常患者（分别为4.79±0.83、1.33±0.36、2.87±0.76和1.11 [0.81 - 1.43] mmol/L）相比，无显著差异。多元回归分析显示促甲状腺激素与血清脂质水平之间无关联。
这些结果表明，在我们的研究人群中，甲状腺功能正常和减退的糖尿病患者血清胆固醇和甘油三酯水平无显著差异。
