Jones Sylwia, Rappoport Joshua Z
School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Nikon Imaging Center at Northwestern University, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, United States.
Int J Biochem Cell Biol. 2014 Jun;51:23-8. doi: 10.1016/j.biocel.2014.03.014. Epub 2014 Mar 27.
Epidermal growth factor (EGF) receptor (EGFR) signalling regulates diverse cellular functions, promoting cell proliferation, differentiation, migration, cell growth and survival. EGFR signalling is critical during embryogenesis, in particular in epithelial development, and disruption of the EGFR gene results in epithelial immaturity and perinatal death. EGFR signalling also functions during wound healing responses through accelerating wound re-epithelialisation, inducing cell migration, proliferation and angiogenesis. Upregulation of EGFR signalling is often observed in carcinomas and has been shown to promote uncontrolled cell proliferation and metastasis. Therefore aberrant EGFR signalling is a common target for anticancer therapies. Various reports indicate that EGFR signalling primarily occurs at the plasma membrane and EGFR degradation following endocytosis greatly attenuates signalling. Other studies argue that EGFR internalisation is essential for complete activation of downstream signalling cascades and that endosomes can serve as signalling platforms. The aim of this review is to discuss current understanding of intersection between EGFR signalling and trafficking.
表皮生长因子（EGF）受体（EGFR）信号传导调节多种细胞功能，促进细胞增殖、分化、迁移、细胞生长和存活。EGFR信号传导在胚胎发生过程中至关重要，尤其是在上皮发育中，EGFR基因的破坏会导致上皮不成熟和围产期死亡。EGFR信号传导在伤口愈合反应中也发挥作用，通过加速伤口再上皮化、诱导细胞迁移、增殖和血管生成来实现。EGFR信号传导的上调在癌症中经常被观察到，并且已被证明会促进不受控制的细胞增殖和转移。因此，异常的EGFR信号传导是抗癌治疗的常见靶点。各种报告表明，EGFR信号传导主要发生在质膜上，内吞作用后EGFR的降解会大大减弱信号传导。其他研究认为，EGFR内化对于下游信号级联反应的完全激活至关重要，并且内体可以作为信号平台。本综述的目的是讨论目前对EGFR信号传导与运输之间交叉点的理解。
