Shi Meiting, Sun Lu, Wei Jiachun, Shen Yao, Wang Jian, Zhang Ping, Yang Xiaofeng, Ding Yuzhen, Yin Wanchang, Lu Xinyao, Yang Xuesong, Wang Guang, Li Ruiman
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
International Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.
Commun Biol. 2025 Jan 20;8(1):90. doi: 10.1038/s42003-025-07547-5.
Preeclampsia (PE) is a pregnancy-specific complication and there remains no effective treatment. Given the limitations on medication use during pregnancy, exploring natural, safe, and effective drugs for PE is worthwhile. We investigate the causal relationship between ferroptosis, inflammation, and PE, and determine the protective effects of quercetin (QCT), a representative compound that is classified as a flavanol, against endothelial dysfunction. Then, the target of QCT is predicted and verified. The prophylactic addition of a low dose of QCT rescues endothelial dysfunction, aiding in endothelial repair. Furthermore, QCT alleviates PE-like maternal manifestations and endothelial dysfunction in the placenta of the selective reduced uteroplacental perfusion (sRUPP) rat model through binding to the epidermal growth factor receptor (EGFR). The potential applications of QCT are expanded, offering the possibility of further development as a safe and effective preventive molecule for PE.
子痫前期（PE）是一种妊娠特有的并发症，目前仍没有有效的治疗方法。鉴于孕期用药的限制，探索用于子痫前期的天然、安全且有效的药物是值得的。我们研究了铁死亡、炎症与子痫前期之间的因果关系，并确定了槲皮素（QCT）（一种归类为黄烷醇的代表性化合物）对内皮功能障碍的保护作用。然后，对QCT的靶点进行预测和验证。预防性添加低剂量的QCT可挽救内皮功能障碍，有助于内皮修复。此外，QCT通过与表皮生长因子受体（EGFR）结合，减轻了选择性子宫胎盘灌注减少（sRUPP）大鼠模型胎盘中的子痫前期样母体表现和内皮功能障碍。槲皮素的潜在应用范围得以扩展，为其作为一种安全有效的子痫前期预防分子进一步开发提供了可能性。
