某机构念珠菌分离株的抗真菌药敏情况。

Antifungal susceptibility of Candida isolates at one institution.

作者信息

Katsuragi Shinji, Sata Makoto, Kobayashi Yoshinari, Miyoshi Takekazu, Yamashita Yasuki, Neki Reiko, Horiuchi Chinami, Yamanaka Kaoru, Kamiya Chizuko, Iwanaga Naoko, Tanaka Hiroaki, Ikeda Tomoaki, Yoshimatsu Jun

机构信息

National Cerebral and Cardiovascular Center.

出版信息

Med Mycol J. 2014;55(1):E1-7. doi: 10.3314/mmj.55.e1.

DOI:10.3314/mmj.55.e1

PMID:24682093

Abstract

Species distribution and antifungal susceptibility of Candida isolates at one institution were evaluated. Detection rates of fungi were examined for 5 years between 2007 and 2011. Sensitivities of fungi to amphotericin B, flucytosine, fluconazole, micafungin, itraconazole, and voriconazole were evaluated in blood culture-positive patients. A total of 3,832 fungal isolates were detected, including Candida albicans 66.5%, Candida glabrata 20.3%, Candida parapsilosis 6.2%, Candida tropicalis 5.5%, and others 1.5%. Candidemia was diagnosed in 131 patients, and C. albicans, C. parapsilosis, C. glabrata, C. tropicalis, and others were present in 42.0%, 27.5%, 16.0%, 8.4%, and 6.1% of these patients, respectively. Voriconazole had the lowest MIC90s against C. albicans and C. parapsilosis (0.015 and 0.25). Micafungin had a low MIC90 against C. glabrata and C. tropicalis. C. albicans was the most common fungus in patients with candidemia. Voriconazole and micafungin were effective against C. albicans. Amphotericin B was effective for C. parapsilosis, and micafungin showed good efficacy against C. glabrata and C. tropicalis.

摘要

评估了某机构念珠菌分离株的菌种分布及抗真菌药敏情况。对2007年至2011年这5年间的真菌检出率进行了检查。对血培养阳性患者评估了真菌对两性霉素B、氟胞嘧啶、氟康唑、米卡芬净、伊曲康唑和伏立康唑的敏感性。共检测到3832株真菌分离株，其中白色念珠菌占66.5%，光滑念珠菌占20.3%，近平滑念珠菌占6.2%，热带念珠菌占5.5%，其他占1.5%。131例患者被诊断为念珠菌血症，其中白色念珠菌、近平滑念珠菌、光滑念珠菌、热带念珠菌及其他分别占这些患者的42.0%、27.5%、16.0%、8.4%和6.1%。伏立康唑对白色念珠菌和近平滑念珠菌的MIC90最低（分别为0.015和0.25）。米卡芬净对光滑念珠菌和热带念珠菌的MIC90较低。白色念珠菌是念珠菌血症患者中最常见的真菌。伏立康唑和米卡芬净对白色念珠菌有效。两性霉素B对近平滑念珠菌有效，米卡芬净对光滑念珠菌和热带念珠菌显示出良好疗效。