Arai K, Hotokebuchi T, Miyahara H, Arita C, Mohtai M, Sugioka Y, Kaibara N
Department of Orthopedic Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Transplant Proc. 1989 Feb;21(1 Pt 3):3191-3.
The effect of the new immunosuppressive agent FK-506 on rat limb allograft was investigated across the BN-to-F344 histocompatibility barrier. A 14-day course of FK-treatment at doses of 1 mg/kg per day or more, begun on the day of operation, significantly increased the period of graft survival. Additional studies demonstrated that single treatment with FK only on the day of operation prolonged the graft survival in a dose-dependent manner. These results stress the profound immunosuppressive effect of FK and suggest the possible future application of composite tissue allograft in humans.
研究了新型免疫抑制剂FK-506跨越BN到F344组织相容性屏障对大鼠肢体同种异体移植的影响。从手术当天开始，以每天1毫克/千克或更高剂量进行14天的FK治疗疗程，显著延长了移植物存活期。进一步研究表明，仅在手术当天单次使用FK，移植物存活期会以剂量依赖方式延长。这些结果强调了FK的强大免疫抑制作用，并提示了复合组织同种异体移植在人类未来可能的应用。
Zotero 插件