Sachdeva Harshita, Saroj Rekha, Dwivedi Diksha
Department of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, Rajasthan 332311, India.
ScientificWorldJournal. 2014 Feb 5;2014:427195. doi: 10.1155/2014/427195. eCollection 2014.
A simple catalytic protocol for the synthesis of novel spiro[indoline-pyranodioxine] derivatives has been developed using ZnO nanoparticle as an efficient, green, and reusable catalyst. The derivatives are obtained in moderate to excellent yield by one-pot three-component reaction of an isatin, malononitrile/ethylcyanoacetate, and 2,2-dimethyl-1,3-dioxane-4,6-dione in absolute ethanol under conventional heating and microwave irradiation. The catalyst was recovered by filtration from the reaction mixture and reused during five consecutive runs without any apparent loss of activity for the same reaction. The mild reaction conditions and recyclability of the catalyst make it environmentally benign synthetic procedure.
已开发出一种简单的催化方法，以氧化锌纳米颗粒作为高效、绿色且可重复使用的催化剂来合成新型螺[吲哚啉 - 吡喃二氧六环]衍生物。通过在绝对乙醇中，在常规加热和微波辐射条件下，使异吲哚酮、丙二腈/氰基乙酸乙酯与2,2 - 二甲基 - 1,3 - 二氧六环 - 4,6 - 二酮进行一锅三组分反应，以中等至优异的产率获得这些衍生物。通过过滤从反应混合物中回收催化剂，并在连续五次运行中重复使用，对同一反应而言其活性没有明显损失。温和的反应条件以及催化剂的可回收性使其成为一种环境友好的合成方法。
