Wu Yu, Hu Xianjing, Song Liyan, Zhu Jianhua, Yu Rongmin
Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
Department of Pharmacology, Jinan University, Guangzhou 510632, China.
ScientificWorldJournal. 2014 Feb 9;2014:768938. doi: 10.1155/2014/768938. eCollection 2014.
Inflammation is known to be closely associated with the development of cancer. The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resource Arca subcrenata. The basic research showed that P2 could suppress the production of nitric oxide in LPS-induced RAW264.7 macrophage cells as well as the secretion of inflammatory cytokines IL-6 and TNF- α in human cervical cancer HeLa cells. For the molecular mechanisms, P2 was shown to downregulate the gene expression of proinflammatory cytokines IL-6 and IL-8 and to inhibit the COX-2 and iNOS-related pathways in HeLa cells. In consequence, P2 might inhibit tumor development by blocking the interaction between tumor microenvironment and proinflammatory mediators. All findings indicate that P2 possesses the potential to be developed as a novel agent for cancer therapy.
已知炎症与癌症的发展密切相关。该研究在人宫颈癌HeLa细胞中展开,以探究来自重要渔业资源皱纹盘鲍的海洋多肽组分P2的抗肿瘤和抗炎作用。基础研究表明,P2可抑制脂多糖诱导的RAW264.7巨噬细胞中一氧化氮的产生,以及人宫颈癌HeLa细胞中炎性细胞因子IL-6和TNF-α的分泌。关于分子机制,P2被证明可下调HeLa细胞中促炎细胞因子IL-6和IL-8的基因表达,并抑制COX-2和iNOS相关途径。因此,P2可能通过阻断肿瘤微环境与促炎介质之间的相互作用来抑制肿瘤发展。所有研究结果表明,P2具有开发成为新型癌症治疗药物的潜力。