黑山共和国肺癌发病率按组织学类型的变化趋势
Changing trends in incidence of lung cancer by histological type in Montenegro.
作者信息
Medenica Milić, Medenica Miras, Bojović Olivera, Soldatović Ivan, Durutović Ivana
出版信息
Srp Arh Celok Lek. 2014 Jan-Feb;142(1-2):23-8. doi: 10.2298/sarh1402023m.
INTRODUCTION
Lung cancer is one of the most common malignant neoplasms, as well as the most common cause of death cancer. Most lung cancers are squamous cell carcinomas, small cell carcinomas or adenocarcinomas.
OBJECTIVE
Examining changes in trends of lung cancer incidence in Montenegro by histological type during a 15-year period, from 1997 to 2011.
METHODS
During the study period, histopathological confirmation was obtained for all primary lung cancer cases in the only hospital for lung diseases in the country. Based on the data from medical records, patients were classified by time period, sex, age groups and smoking history. Descriptive method was used.
RESULTS
Ratio between incidences of adenocarcinoma and squamous cell carcinoma changes in males, with a significant increase in the incidence rate of adenocarcinoma and drop in the rate of squamous cell carcinoma (p < 0.001). In addition, statistically significant (p < 0.05) decrease in the incidence of NSCLC (non-small cell lung cancer) and an increase in the incidence of SCLC (small cell lung cancer) was found. A statistically significant increase in linear trend in the incidence of small cell carcinoma was noted in females (p < 0.005).
CONCLUSION
Incidence rates of adenocarcinoma and small cell carcinoma have increased during the study period.
引言
肺癌是最常见的恶性肿瘤之一，也是癌症死亡的最常见原因。大多数肺癌为鳞状细胞癌、小细胞癌或腺癌。
目的
研究1997年至2011年这15年间黑山共和国肺癌发病率按组织学类型的变化趋势。
方法
在研究期间，该国唯一的肺病医院对所有原发性肺癌病例进行了组织病理学确诊。根据病历数据，对患者按时间段、性别、年龄组和吸烟史进行分类。采用描述性方法。
结果
男性腺癌和鳞状细胞癌发病率之比发生变化，腺癌发病率显著上升，鳞状细胞癌发病率下降（p<0.001）。此外，非小细胞肺癌（NSCLC）发病率有统计学意义的下降（p<0.05），小细胞肺癌（SCLC）发病率上升。女性小细胞癌发病率的线性趋势有统计学意义的增加（p<0.005）。
结论
在研究期间，腺癌和小细胞癌的发病率有所上升。
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