Epstein J, Warner J O
Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, London, UK.
Clin Exp Allergy. 2014 Jun;44(6):802-12. doi: 10.1111/cea.12316.
Eosinophilic oesophagitis is an increasingly recognized allergic gastrointestinal disease, which is becoming more common. Although the average age at diagnosis is 30-50 years, it often affects very young children and carries significant long-term morbidity. While our understanding of its pathophysiology is accumulating, the precise pathways by which the disease arises remain unclear. There are inconsistencies in its diagnosis and definition, and a drive towards international standardization is underway. Current methods for diagnosis and monitoring are relatively invasive, and controversies surround their interpretation. Management strategies are imperfect and involve burdensome long-term dietary exclusions, or drug treatments with uncertain efficacy or serious side-effects. It is the focus of a rapidly increasing body of research, the latest insights from which are systematically presented in this review.
嗜酸性粒细胞性食管炎是一种日益被认识的过敏性胃肠道疾病，且正变得越来越常见。虽然诊断的平均年龄为30至50岁，但它常影响非常年幼的儿童，并伴有严重的长期发病率。尽管我们对其病理生理学的认识在不断积累，但该疾病发生的确切途径仍不清楚。其诊断和定义存在不一致之处，目前正在推动国际标准化。目前的诊断和监测方法相对具有侵入性，且对其解读存在争议。管理策略并不完善，包括繁琐的长期饮食排除法，或疗效不确定或有严重副作用的药物治疗。它是快速增长的研究领域的焦点，本综述系统地介绍了该领域的最新见解。
