Gillani Syed Wasif, Rahmatillah Diana Laila, Sari Yelly Oktavia, Baig Mirza R, Syed Sulaiman Syed Azhar
School of Pharmacy, Monash University Malaysia, PO box 46150, Bandar Sunway, Selangor, Malaysia.
Int Arch Med. 2014 Apr 1;7(1):13. doi: 10.1186/1755-7682-7-13.
Hyperglycemia and hypocalcaemia have separately been attributed to adverse outcomes in critically ill patients. The study was aim determine whether hyperglycemia and hypocalcaemia together post-operative effect of thyroidectomy and evaluate the gender & age impact on the extend of clinical condition.
All the patients underwent thyroidectomy in the duration of 1st Jan 2012 till 30th June, 2013 in HPP and HUSM Kelantan, Malaysia. Serum evaluation has been made on 4 consecutive reading with duration of 6 hours. The predictive trend has been established to identify the hypokalemic and hyperglycemic condition. Ethical approvals & Patients' consent forms have been made prior to conduct this study.
The incidence of hyperglycemia [≥ 150 mg/dl(8.3 mmol/L)] and hypocalcaemia (serum calcium < 8.5 mg/dl (2.2 mmol/L)] were 39.4% and 43.9% respectively. Hyperglycemia and hypocalcaemia associated with age and length of stay, significant association has been found among pre-operative diagnosis as well. The interaction of hyperglycemia and hypocalcaemia did not separate effects on mortality.
As demonstrated, the prevalence of hyperglycemia and hypocalcaemia in post-thyroidectomy patients is considerable high. Also, the linear association pattern has been shown. However, considering the disease severity, the association of hyperglycemia and hypocalcaemia with surgical ward indicators of morbidity could not be verified.
高血糖和低钙血症分别被认为与危重症患者的不良预后有关。本研究旨在确定高血糖和低钙血症共同对甲状腺切除术后的影响,并评估性别和年龄对临床病情严重程度的影响。
选取2012年1月1日至2013年6月30日在马来西亚吉兰丹州HPP和HUSM接受甲状腺切除术的所有患者。连续4次每6小时进行一次血清评估。建立预测趋势以识别低钾血症和高血糖状态。在开展本研究之前已获得伦理批准并取得患者同意书。
高血糖[≥150mg/dl(8.3mmol/L)]和低钙血症(血清钙<8.5mg/dl(2.2mmol/L))的发生率分别为39.4%和43.9%。高血糖和低钙血症与年龄和住院时间相关,术前诊断之间也存在显著关联。高血糖和低钙血症的相互作用对死亡率没有单独影响。
结果表明,甲状腺切除术后患者高血糖和低钙血症的患病率相当高。此外,还显示出线性关联模式。然而,考虑到疾病的严重程度,高血糖和低钙血症与手术病房发病率指标之间的关联无法得到证实。