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Endocytosis and inositol hexakisphosphate levels in ras transformants of Dictyostelium discoideum amoebae.

作者信息

Klein G, Martin J B, Satre M, Reymond C

机构信息

DRF/LBIO/Biochimie (UA 1130 CNRS), Grenoble, France.

出版信息

Experientia. 1989 Apr 15;45(4):365-7. doi: 10.1007/BF01957480.

DOI:10.1007/BF01957480
PMID:2468517
Abstract

Fluid-phase pinocytosis kinetics and lysosomal enzyme secretion parameters were measured in Dictyostelium discoideum amoebae constructed from strain AX3 by transformation with a multicopy plasmid carrying either a normal ras gene (ras-Gly12), a mutated ras gene (ras-Thr12) or by the vector carrying the geneticin resistance gene only (pDNEO2). It was found that the pinocytosis rate and extent as well as the lysosomal enzyme secretion were slightly different in the three strains. These changes, however, were related to minor modifications of the cellular volumes. The overall concentration of inositol hexakisphosphate was similar in the three strains.

摘要

相似文献

1
Endocytosis and inositol hexakisphosphate levels in ras transformants of Dictyostelium discoideum amoebae.
Experientia. 1989 Apr 15;45(4):365-7. doi: 10.1007/BF01957480.
2
Mutant ras gene induces elevated levels of inositol tris- and hexakisphosphates in Dictyostelium.突变型ras基因可诱导盘基网柄菌中肌醇三磷酸和肌醇六磷酸水平升高。
J Cell Sci. 1988 Jan;89 ( Pt 1):13-20. doi: 10.1242/jcs.89.1.13.
3
Kinetics of fluid-phase pinocytosis in Dictyostelium discoideum amoebae.盘基网柄菌变形虫中液相胞饮作用的动力学
Biochem Biophys Res Commun. 1986 Aug 14;138(3):1146-52. doi: 10.1016/s0006-291x(86)80402-8.
4
Endo-lysosomal acidification in Dictyostelium discoideum amoebae. Effects of two endocytosis inhibitors: caffeine and cycloheximide.盘基网柄菌变形虫中的内溶酶体酸化。两种内吞作用抑制剂的影响：咖啡因和环己酰亚胺。
Eur J Cell Biol. 1993 Aug;61(2):225-8.
5
Increased conversion of phosphatidylinositol to phosphatidylinositol phosphate in Dictyostelium cells expressing a mutated ras gene.在表达突变型ras基因的盘基网柄菌细胞中，磷脂酰肌醇向磷脂酰肌醇磷酸的转化率增加。
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9197-201. doi: 10.1073/pnas.87.23.9197.
6
A new collection of thermosensitive endocytosis mutants in the cellular slime mold Dictyostelium discoideum.盘基网柄菌中一组新的热敏内吞作用突变体。
J Eukaryot Microbiol. 1997 Nov-Dec;44(6):620-5. doi: 10.1111/j.1550-7408.1997.tb05969.x.
7
Kinetics of endosomal acidification in Dictyostelium discoideum amoebae. 31P-NMR evidence for a very acidic early endosomal compartment.盘基网柄菌变形虫内体酸化的动力学。31P-NMR证据表明存在一个非常酸性的早期内体区室。
Biochimie. 1992 Sep-Oct;74(9-10):883-95. doi: 10.1016/0300-9084(92)90072-m.
8
Expression of a mutated ras gene in Dictyostelium discoideum alters the binding of cyclic AMP to its chemotactic receptor.在盘基网柄菌中，突变型ras基因的表达改变了环磷酸腺苷与其趋化受体的结合。
J Cell Sci. 1988 Aug;90 ( Pt 4):701-6. doi: 10.1242/jcs.90.4.701.
9
Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts.溶酶体的碱化与小鼠和人类成纤维细胞的ras转化相关。
J Biol Chem. 1990 Mar 25;265(9):4775-7.
10
Giant vacuoles observed in Dictyostelium discoideum.在盘基网柄菌中观察到巨大液泡。
Cell Biol Int. 2001;25(2):147-55. doi: 10.1006/cbir.2000.0577.

引用本文的文献

1
Nucleus-associated phosphorylation of Ins(1,4,5)P3 to InsP6 in Dictyostelium.盘基网柄菌中Ins(1,4,5)P3向InsP6的细胞核相关磷酸化作用
Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):911-7.
2
Increased conversion of phosphatidylinositol to phosphatidylinositol phosphate in Dictyostelium cells expressing a mutated ras gene.在表达突变型ras基因的盘基网柄菌细胞中，磷脂酰肌醇向磷脂酰肌醇磷酸的转化率增加。
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9197-201. doi: 10.1073/pnas.87.23.9197.

本文引用的文献

1
Kinetics of membrane internalization and recycling during pinocytosis in Dictyostelium discoideum.盘基网柄菌胞饮作用过程中膜内化与循环的动力学
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1015-9. doi: 10.1073/pnas.77.2.1015.
2
Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian ras protein.一种编码与哺乳动物ras蛋白同源的蛋白质的盘基网柄菌基因的发育调控。
Cell. 1984 Nov;39(1):141-8. doi: 10.1016/0092-8674(84)90199-5.
3
Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture.
细胞黏菌盘基网柄菌的黏变形体在无菌培养中的生长。
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4
Regulated expression of ras gene constructs in Dictyostelium transformants.盘基网柄菌转化体中ras基因构建体的调控表达。
Proc Natl Acad Sci U S A. 1985 Oct;82(20):7005-9. doi: 10.1073/pnas.82.20.7005.
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Regulation of membrane turnover by ras proteins.Ras蛋白对膜周转的调控。
Biosci Rep. 1987 May;7(5):427-34. doi: 10.1007/BF01362505.
6
The ras protein is not associated with exocytosis.ras蛋白与胞吐作用无关。
Nature. 1987;328(6131):581. doi: 10.1038/328581a0.
7
Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.盘基网柄菌转化体发育过程中由突变的ras基因诱导的表型变化。
Nature. 1986;323(6086):340-3. doi: 10.1038/323340a0.
8
Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins.Ras蛋白诱导静止成纤维细胞形成膜皱褶和液相胞饮作用。
Science. 1986 Sep 5;233(4768):1061-8. doi: 10.1126/science.3090687.
9
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.正常的p21N-ras将蛙皮素和其他生长因子受体与肌醇磷酸的产生联系起来。
Nature. 1986;323(6084):173-6. doi: 10.1038/323173a0.
10
Aberrant transmembrane signal transduction in Dictyostelium cells expressing a mutated ras gene.表达突变型ras基因的盘基网柄菌细胞中的异常跨膜信号转导。
Proc Natl Acad Sci U S A. 1987 Jul;84(14):4905-9. doi: 10.1073/pnas.84.14.4905.