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[肠道微生物群与多糖的消化]

[Gut microbiota and digestion of polysaccharides].

作者信息

El Kaoutari Abdessamad, Armougom Fabrice, Raoult Didier, Henrissat Bernard

机构信息

Centre national de la recherche scientifique, UMR 7257, 13288 Marseille, France - URMITE, UM63, CNRS 7278, Institut de recherche pour le développement 198, Inserm 1095, université Aix-Marseille, faculté de médecine, Marseille, France.

URMITE, UM63, CNRS 7278, Institut de recherche pour le développement 198, Inserm 1095, université Aix-Marseille, faculté de médecine, Marseille, France.

出版信息

Med Sci (Paris). 2014 Mar;30(3):259-65. doi: 10.1051/medsci/20143003013. Epub 2014 Mar 31.

Abstract

The distal gut microbiota corresponds to all the microorganisms, essentially bacteria, that reside commonly in the colon. The microbial population is characterized by a large taxonomical diversity, counting approximately a thousand distinct bacterial species for a single individual. The pace of investigations of this microbial system has greatly accelerated these last few years, fuelled by the advent of metagenomics techniques, which do not rely on bacterial cultivation, but utilize high throughput DNA sequencing. In just a few years studies of the intestinal microbiota have become fashionable, albeit with often contradictory results when attempting to correlate changes in microbial composition to diverse pathologies. The article focuses on one of the essential functions of the distal gut microbiota: the digestion of the immense variety of polysaccharides from our diet that enzymes of the host cannot breakdown.

摘要

远端肠道微生物群对应于通常存在于结肠中的所有微生物,主要是细菌。微生物群体的特点是具有很大的分类学多样性,单个个体大约有一千种不同的细菌物种。近年来,由于宏基因组学技术的出现,对这个微生物系统的研究步伐大大加快。宏基因组学技术不依赖细菌培养,而是利用高通量DNA测序。短短几年间,肠道微生物群的研究变得流行起来,尽管在试图将微生物组成的变化与各种疾病联系起来时,结果往往相互矛盾。本文重点关注远端肠道微生物群的一项基本功能:消化我们饮食中宿主酶无法分解的大量多糖。

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