Pareja-Sierra Teresa
Sección de Geriatría, Hospital Universitario de Guadalajara, Sescam, Guadalajara, España.
Rev Esp Geriatr Gerontol. 2014 Jul-Aug;49(4):188-93. doi: 10.1016/j.regg.2014.02.006. Epub 2014 Mar 27.
Infection due to Clostridium difficile is currently the main cause of hospital acquired gastrointestinal disease. Its prevalence in the elderly population is higher due to there being many associated risk factors in this age group, such as comorbidity, frequent exposure to the healthcare or residential home setting, immunosenescence, greater consumption of antibiotics, and antiacids. The diagnostic techniques have notably improved in the last few years, which could also account for an increase in its diagnosis. The new expert consensus recommendations propose stratifying the clinical situation of the patient in order to choose the treatment option. Therapeutic options have recently been included in the new Clinical Guidelines, such as flidaxomicin or fecal transplants, with encouraging results, particularly for the control of frequent recurrences.
艰难梭菌感染是目前医院获得性胃肠道疾病的主要病因。由于该年龄组存在许多相关风险因素，如合并症、频繁接触医疗保健机构或养老院环境、免疫衰老、大量使用抗生素和抗酸剂等，其在老年人群中的患病率更高。在过去几年中，诊断技术有了显著改进，这也可能是其诊断率上升的原因。新的专家共识建议对患者的临床情况进行分层，以便选择治疗方案。最近新的临床指南纳入了一些治疗选择，如非达霉素或粪便移植，取得了令人鼓舞的结果，尤其是在控制频繁复发方面。
