de Cássia Ribeiro-Silva Rita, Fiaccone Rosemeire Leovigildo, Barreto Maurício Lima, da Silva Luce Alves, Santos Luis Fernandes Pereira, Alcantara-Neves Neuza Maria
Departamento de Ciências da Nutrição, Universidade Federal da Bahia, Av. Araújo Pinho, 32, Canela, CEP: 40110-150 Salvador, Bahia, Brazil.
Instituto de Matemática, Universidade Federal da Bahia, Av. Adhemar de Barros, s/n, Ondina, CEP: 40170-110 Salvador, Bahia, Brazil.
J Trace Elem Med Biol. 2014 Jul;28(3):293-7. doi: 10.1016/j.jtemb.2014.02.007. Epub 2014 Mar 10.
To assess the influence of zinc serum status on the prevalence of wheezing in a sample of children and adolescents in Northeastern Brazil.
This is a cross-sectional study which included 592 students of 6-12 years old, from the public elementary schools of São Francisco do Conde, Bahia, Northeastern Brazil. Report of wheezing in the past 12 months was collected using a questionnaire of the International Study of Asthma and Allergies in Childhood Program (ISAAC) phase III, adapted to Portuguese. The determination of serum Zn levels was performed using a flame atomic absorption spectrometer. Data on anthropometric status, level of physical activity, pubertal development and socioeconomic information, for each participant were obtained. Multivariate logistic regression analyses were used to assess the associations of interest.
Of the students, 8.6% (95% CI 6.30-10.9) reported having wheezing. The mean (SD) serum zinc level was 114 (22.9 μg/dL). The results of the multiple logistic regression analysis showed, after adjustments, positive and significant association between low serum zinc levels and wheezing. Students categorized as being below the median for serum Zn concentration presented an almost 1.9-fold increase in the wheezing prevalence ratio (OR=1.9; 95% CI 1.03-3.53).
The main findings of this study suggest that the level of zinc may influence the risk of wheezing in late childhood on the study population.
评估巴西东北部儿童和青少年样本中血清锌水平对喘息患病率的影响。
这是一项横断面研究，纳入了来自巴西东北部巴伊亚州圣弗朗西斯科 - 杜康德公立小学的592名6至12岁的学生。使用适用于葡萄牙语的儿童哮喘和过敏国际研究计划（ISAAC）第三阶段问卷收集过去12个月内喘息的报告。使用火焰原子吸收光谱仪测定血清锌水平。获取了每位参与者的人体测量状况、身体活动水平、青春期发育和社会经济信息数据。采用多因素逻辑回归分析来评估相关关联。
在这些学生中，8.6%（95%可信区间6.30 - 10.9）报告有喘息。血清锌水平的均值（标准差）为114（22.9μg/dL）。多因素逻辑回归分析结果显示，调整后血清锌水平低与喘息之间存在正相关且具有统计学意义。血清锌浓度处于中位数以下的学生喘息患病率比值增加了近1.9倍（比值比 = 1.9；95%可信区间1.03 - 3.53）。
本研究的主要发现表明，锌水平可能会影响研究人群中儿童晚期喘息的风险。
