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家族性梅尼埃病患者自身免疫性疾病患病率更高且眩晕发作时间更长:家族性与散发性梅尼埃病的临床比较

Higher prevalence of autoimmune diseases and longer spells of vertigo in patients affected with familial Ménière's disease: A clinical comparison of familial and sporadic Ménière's disease.

作者信息

Hietikko Elina, Sorri Martti, Männikkö Minna, Kotimäki Jouko

出版信息

Am J Audiol. 2014 Jun;23(2):232-7. doi: 10.1044/2014_AJA-13-0060.

Abstract

PURPOSE This study compared clinical features, predisposing factors, and concomitant diseases between sporadic and familial Ménière's disease (MD). METHOD Retrospective chart review and postal questionnaire were used. Participants were 250 definite patients with MD (sporadic, n =149; familial, n = 101) who fulfilled the American Academy of Otorhinolaryngology-Head and Neck Surgery (1995) criteria. RESULTS On average, familial patients were affected 5.6 years earlier than sporadic patients, and they suffered from significantly longer spells of vertigo (p = .007). The prevalence of rheumatoid arthritis (p = .002) and other autoimmune diseases (p = .046) was higher among the familial patients, who also had more migraine (p = .036) and hearing impairment (p = .002) in their families. CONCLUSION The clinical features of familial and sporadic MD are very similar in general, but some differences do exist. Familial MD patients are affected earlier and suffer from longer spells of vertigo.

摘要

目的 本研究比较散发性和家族性梅尼埃病(MD)的临床特征、诱发因素及伴发疾病。方法 采用回顾性病历审查和邮寄问卷调查。研究对象为250例符合美国耳鼻咽喉头颈外科学会(1995年)标准的确诊MD患者(散发性,n = 149;家族性,n = 101)。结果 家族性患者发病平均比散发性患者早5.6年,且眩晕发作时间显著更长(p = .007)。家族性患者中类风湿关节炎(p = .002)和其他自身免疫性疾病(p = .046)的患病率更高,其家族中偏头痛(p = .036)和听力障碍(p = .002)也更多。结论 家族性和散发性MD的临床特征总体非常相似,但确实存在一些差异。家族性MD患者发病更早,眩晕发作时间更长。

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