梅尼埃病的遗传学
The genetics of Ménière's disease.
作者信息
Chiarella Giuseppe, Petrolo C, Cassandro E
机构信息
Department of experimental and Clinical Medicine, Audiology and Phoniatrics Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
出版信息
Appl Clin Genet. 2015 Jan 8;8:9-17. doi: 10.2147/TACG.S59024. eCollection 2015.
Abstract
Our understanding of the genetic basis of Ménière's disease (MD) is still limited. Although the familial clustering and the geographical and racial differences in incidence strongly suggest a certain role for genetic factors in the development of MD, no convincing evidence for an association with any gene exists, at present. In this review, starting from rational bases for a genetic approach to MD, we explored the numerous reports published in literature and summarize the recent advances in understanding of the genetic fundaments of the disease.
摘要
我们对梅尼埃病（MD）遗传基础的理解仍然有限。尽管家族聚集性以及发病率在地理和种族上的差异有力地表明遗传因素在MD的发病过程中起到了一定作用，但目前尚无令人信服的证据表明其与任何基因存在关联。在本综述中，我们从对MD进行遗传学研究的合理依据出发，探讨了文献中发表的众多报告，并总结了对该疾病遗传基础理解的最新进展。
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