Weinberger M H
Hypertension Research Center, Indiana University School of Medicine, Indianapolis 46223.
J Cardiovasc Pharmacol. 1988;12 Suppl 4:S72-5. doi: 10.1097/00005344-198806124-00014.
The role of dietary sodium intake and diuretic administration on the blood pressure response to calcium channel blockers (CCB) is reviewed. CCB has been shown to have a natriuretic effect irrespective of sodium balance state. Sodium-sensitive hypertensives often have lower blood pressure levels after dietary sodium restriction or diuretic therapy, making the additive benefit of CCB on blood pressure more difficult to discern. The majority of studies including appropriate controls suggest that CCBs of the dihydropyridine class (nifedipine and nitrendipine) and also verapamil have an antihypertensive effect that can be augmented by diuretic administration.
本文综述了膳食钠摄入和利尿剂使用对钙通道阻滞剂（CCB）血压反应的作用。已证明CCB无论钠平衡状态如何都具有利钠作用。钠敏感性高血压患者在进行膳食钠限制或利尿剂治疗后，血压水平通常会降低，这使得CCB对血压的附加益处更难辨别。大多数包含适当对照的研究表明，二氢吡啶类CCB（硝苯地平和尼群地平）以及维拉帕米具有降压作用，利尿剂使用可增强这种作用。
