Mulvany M J
Biophysics Institute, Aarhus University, Denmark.
J Cardiovasc Pharmacol. 1988;12 Suppl 6:S16-20. doi: 10.1097/00005344-198812006-00006.
Many investigators have shown that vascular smooth muscle from hypertensive individuals shows oscillatory activity, i.e., spontaneous or rhythmic contractions. This paper reviews work performed in the author's laboratory designed to determine if the oscillatory activity of mesenteric resistance vessels taken from spontaneously hypertensive rats (SHR) is associated with the cause of the high blood pressure in these animals, as well as to determine the mechanism producing the oscillatory activity. Cross-breeding of SHR and normotensive control Wistar-Kyoto rats (WKY) was used to produce F2-SHR/WKY rats. In the F2-SHR/WKY rats, there was a correlation between systolic blood pressure and mesenteric resistance vessel oscillatory activity, but no correlation between systolic blood pressure and mesenteric resistance vessel calcium sensitivity. The oscillatory activity appeared to be associated with changes in membrane potential and is inhibited by inhibitors of potential-dependent calcium channels. This is consistent with reports from other laboratories that the oscillatory activity could be associated with an interaction between potential-dependent calcium channels and calcium-dependent potassium channels. The results suggest that the increased oscillatory activity of the mesenteric resistance vessels of the SHR is associated with a cause of high blood pressure in these animals and may be due to an abnormal activity of the calcium-dependent potassium channels.
许多研究者已表明，高血压患者的血管平滑肌会出现振荡活动，即自发或有节律的收缩。本文回顾了作者实验室开展的工作，旨在确定取自自发性高血压大鼠（SHR）的肠系膜阻力血管的振荡活动是否与这些动物的高血压病因相关，以及确定产生振荡活动的机制。通过将SHR与血压正常的对照Wistar-Kyoto大鼠（WKY）进行杂交来培育F2-SHR/WKY大鼠。在F2-SHR/WKY大鼠中，收缩压与肠系膜阻力血管振荡活动之间存在相关性，但收缩压与肠系膜阻力血管钙敏感性之间无相关性。振荡活动似乎与膜电位变化有关，并受到电压依赖性钙通道抑制剂的抑制。这与其他实验室的报告一致，即振荡活动可能与电压依赖性钙通道和钙依赖性钾通道之间的相互作用有关。结果表明，SHR肠系膜阻力血管振荡活动增加与这些动物的高血压病因相关，可能是由于钙依赖性钾通道的异常活动所致。
