Sporea Ioan, Martie Alina, Bota Simona, Sirli Roxana, Popescu Alina, Dănila Mirela
Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timisoara, Romania.
J Gastrointestin Liver Dis. 2014 Mar;23(1):57-63.
To present a large monocentric experience in the characterization of focal liver lesions (FLLs) using Contrast Enhanced Ultrasound (CEUS).
A retrospective study was performed in the Gastroenterology and Hepatology Department, Timisoara, including 1100 patients with 1329 FLLs evaluated between September 2009 and January 2013. A CEUS examination was considered conclusive if the FLL respected the typical enhancement pattern as described in the EFSUMB Guidelines.
From the 1329 FLLs, CEUS was conclusive for a specific pathology in 1102 cases (82.9%). For the differentiation of benign/malignant lesions, CEUS reached a conclusive diagnosis in 1196 (90%) cases. The percentage of conclusive CEUS examinations was significantly higher in patients without chronic liver disease as compared with those with chronic hepatopathies: 87.3% vs. 74.4% (p<0.0001).
CEUS patterns of enhancement fell into clear cut specific diagnostic patterns in 83% of the FLLs discovered by US, and into clear cut benign versus malignant patterns in 90% of the cases. For this reason, we can strongly recommend CEUS as a first line imaging method to characterize FLLs found at US, at least in centers with a good experience in CEUS.
介绍一项使用超声造影（CEUS）对肝脏局灶性病变（FLLs）进行特征性分析的大型单中心研究经验。
在蒂米什瓦拉胃肠病学和肝病科进行了一项回顾性研究，纳入2009年9月至2013年1月期间评估的1100例患者的1329个FLLs。如果FLLs符合欧洲超声医学与生物学联合会（EFSUMB）指南中描述的典型增强模式，则CEUS检查被视为结论性的。
在1329个FLLs中，CEUS对1102例（82.9%）的特定病理诊断具有结论性。对于良性/恶性病变的鉴别，CEUS在1196例（90%）中得出结论性诊断。与慢性肝病患者相比，无慢性肝病患者的CEUS结论性检查百分比显著更高：87.3%对74.4%（p < 0.0001）。
在美国发现的FLLs中，83%的CEUS增强模式符合明确的特定诊断模式，90%的病例符合明确的良性与恶性模式。因此，我们强烈推荐CEUS作为表征美国发现的FLLs的一线成像方法，至少在有CEUS良好经验的中心。
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