Ibrahim Sabrin R M
Nat Prod Commun. 2014 Feb;9(2):205-8.
Re-investigation of the MeOH extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) led to the isolation of a new chromone derivative (5,7- dihydroxy-2-[2-(3-methoxy-4-hydroxyphenyl)ethyl]chromone (5) and a triglyceride (1,3-di-(6Z,9Z)-docosa-6,9-dienoyl-2-(6Z) hexacos-6-enoylglycerol (1), together with three known compounds; alpha-spinasterol (2), stigmasta-7,22,25-trien-3-ol (3), and D:B-friedoolean-5-ene-3-beta-ol (4), are reported from this species for the first time. Their structures were determined by extensive 1D (1H, 13C, and DEPT) and 2D (1H-1H COSY, HMQC, and HMBC) NMR and mass spectral measurements. Compound 5 displayed significant cytotoxic activity against L5178Y cells, with an ED50 of 5 microM. The MeOH extract and 5 showed antioxidant activity using the DPPH assay.
对甜瓜（葫芦科，网纹甜瓜变种）种子的甲醇提取物进行再研究，分离得到一种新的色酮衍生物（5,7 - 二羟基 - 2 - [2 - (3 - 甲氧基 - 4 - 羟基苯基)乙基]色酮（5）和一种甘油三酯（1,3 - 二 - (6Z,9Z) - 二十二碳 - 6,9 - 二烯酰基 - 2 - (6Z) - 二十六碳 - 6 - 烯酰基甘油（1），同时还得到三种已知化合物；首次从该物种中报道了α - 菠菜甾醇（2）、豆甾 - 7,22,25 - 三烯 - 3 - 醇（3）和D:B - 呋甾 - 5 - 烯 - 3 - β - 醇（4）。通过广泛的一维（1H、13C和DEPT）和二维（1H - 1H COSY、HMQC和HMBC）核磁共振以及质谱测量确定了它们的结构。化合物5对L5178Y细胞显示出显著的细胞毒性活性，ED50为5 microM。使用DPPH测定法，甲醇提取物和化合物5显示出抗氧化活性。
