Attwood D, Gibson J
J Pharm Pharmacol. 1978 Mar;30(3):176-80. doi: 10.1111/j.2042-7158.1978.tb13192.x.
Light scattering, conductivity and pH methods have been used to examine the aggregation in aqueous solution of a series of antidepressant drugs. The drugs investigated included the hydrochlorides of amitriptyline, butriptyline, protriptyline, nortriptyline, imipramine, desipramine, clomipramine, dothiepin, dibenzepin, opipramol, iprindole, doxepin, mianserin and maprotiline. No significant association of dibenzepin, mianserin or maprotiline hydrochlorides could be detected up to their respective solubility limits. A micellar pattern of association was established for all other compounds. Critical micelle concentrations and micellar properties are reported.
已采用光散射、电导率和pH值方法来研究一系列抗抑郁药物在水溶液中的聚集情况。所研究的药物包括阿米替林、布替林、普罗替林、去甲替林、丙咪嗪、地昔帕明、氯米帕明、多塞平、二苯西平、奥匹哌醇、茚满二酮、多塞平、米安色林和马普替林的盐酸盐。在各自的溶解度极限内，未检测到二苯西平、米安色林或马普替林盐酸盐有明显缔合。为所有其他化合物建立了缔合的胶束模式。报告了临界胶束浓度和胶束性质。
